Salvage chemotherapy for non Hodgkin's lymphoma of unfavourable histology with a combination of CCNU and vinblastine

G. Palmieri, R. Lauria, F. Caponigro, C. Pagliarulo, V. Montesarchio, F. Nuzzo, C. Gridelli, A. R. Bianco

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Abstract

Twenty patients with relapsed or refractory, intermediate or high grade non Hodgkin's lymphoma were treated with a combination of CCNU and vinblastine. Complete responses occurred in four patients (20 per cent), partial responses in eight (40 per cent), for an overall response rate of 60 per cent. The regimen was more effective in patients with high grade lymphoma, absence of constitutional symptoms, better response to prior treatment. Duration of response was 4, 8, 16, 30 months for complete responders; 2, 2, 6, 6, 6, 8, 9, 14 months for partial responders. This combination regimen seems at least as effective as most of other regimens utilized in salvage treatment of non Hodgkin's lymphomas, with a very acceptable toxicity.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalHematological Oncology
Volume8
Issue number4
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Palmieri, G., Lauria, R., Caponigro, F., Pagliarulo, C., Montesarchio, V., Nuzzo, F., Gridelli, C., & Bianco, A. R. (1990). Salvage chemotherapy for non Hodgkin's lymphoma of unfavourable histology with a combination of CCNU and vinblastine. Hematological Oncology, 8(4), 179-183.