Salvage chemotherapy in Hodgkin's disease: Results in patients relapsing more than twelve months after first complete remission

S. Viviani, A. Santoro, E. Negretti, V. Bonfante, P. Valagussa, G. Bonadonna

Research output: Contribution to journalArticle

Abstract

Forty-nine patients with Hodgkin's disease who relapsed after a first complete remission of more than 12 months following primary chemotherapy were treated with salvage therapy regimens. A total of 41 patients (84%) achieved complete remission. In particular, complete response was documented in 17 of 19 patients re-treated with the same initial drug combination. The five-year freedom from progression, relapse-free and overall survivals were 51%, 57% and 65%, respectively. In our experience, consolidation radiotherapy following drug-induced remission failed to improve the five-year relapse-free survival. Present findings indicate that about half of patients relapsing after a disease-free interval exceeding 12 months can remain alive and disease-free 5 years after starting salvage chemotherapy.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalAnnals of Oncology
Volume1
Issue number2
Publication statusPublished - 1990

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Hodgkin Disease
Drug Therapy
Recurrence
Salvage Therapy
Survival
Drug Combinations
Radiotherapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Salvage chemotherapy in Hodgkin's disease : Results in patients relapsing more than twelve months after first complete remission. / Viviani, S.; Santoro, A.; Negretti, E.; Bonfante, V.; Valagussa, P.; Bonadonna, G.

In: Annals of Oncology, Vol. 1, No. 2, 1990, p. 123-127.

Research output: Contribution to journalArticle

Viviani, S, Santoro, A, Negretti, E, Bonfante, V, Valagussa, P & Bonadonna, G 1990, 'Salvage chemotherapy in Hodgkin's disease: Results in patients relapsing more than twelve months after first complete remission', Annals of Oncology, vol. 1, no. 2, pp. 123-127.
Viviani, S. ; Santoro, A. ; Negretti, E. ; Bonfante, V. ; Valagussa, P. ; Bonadonna, G. / Salvage chemotherapy in Hodgkin's disease : Results in patients relapsing more than twelve months after first complete remission. In: Annals of Oncology. 1990 ; Vol. 1, No. 2. pp. 123-127.
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