Salvage chemotherapy in Hodgkin's disease: Results in patients relapsing more than twelve months after first complete remission

S. Viviani, A. Santoro, E. Negretti, V. Bonfante, P. Valagussa, G. Bonadonna

Research output: Contribution to journalArticlepeer-review

Abstract

Forty-nine patients with Hodgkin's disease who relapsed after a first complete remission of more than 12 months following primary chemotherapy were treated with salvage therapy regimens. A total of 41 patients (84%) achieved complete remission. In particular, complete response was documented in 17 of 19 patients re-treated with the same initial drug combination. The five-year freedom from progression, relapse-free and overall survivals were 51%, 57% and 65%, respectively. In our experience, consolidation radiotherapy following drug-induced remission failed to improve the five-year relapse-free survival. Present findings indicate that about half of patients relapsing after a disease-free interval exceeding 12 months can remain alive and disease-free 5 years after starting salvage chemotherapy.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalAnnals of Oncology
Volume1
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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