Abstract
CCNU and methotrexate were employed as salvage treatment in 34 small cell lung cancer patients resistant to CAV/PE alternating induction chemotherapy. In the 33 evaluable patients we observed an objective response rate of 21.2% and 3% complete response; median survival was 4 months with 2 patients alive 18 months from starting salvage chemotherapy. The treatment was well tolerated. CCNU and methotrexate has shown to be a moderately active and tolerable salvage treatment for small cell lung cancer after CAV/PE alternating first-line chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 506-510 |
| Number of pages | 5 |
| Journal | Tumori |
| Volume | 77 |
| Issue number | 6 |
| Publication status | Published - 1991 |
Fingerprint
ASJC Scopus subject areas
- Cancer Research
Cite this
Salvage chemotherapy with CCNU and methotrexate for small cell lung cancer resistant to CAV/PE alternating chemotherapy. / Gridelli, C.; Contegiacomo, A.; Lauria, R.; Gentile, M.; Airoma, G.; De Placido, S.; Perrone, F.; Ferrante, G.; Bianco, A. R.
In: Tumori, Vol. 77, No. 6, 1991, p. 506-510.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Salvage chemotherapy with CCNU and methotrexate for small cell lung cancer resistant to CAV/PE alternating chemotherapy
AU - Gridelli, C.
AU - Contegiacomo, A.
AU - Lauria, R.
AU - Gentile, M.
AU - Airoma, G.
AU - De Placido, S.
AU - Perrone, F.
AU - Ferrante, G.
AU - Bianco, A. R.
PY - 1991
Y1 - 1991
N2 - CCNU and methotrexate were employed as salvage treatment in 34 small cell lung cancer patients resistant to CAV/PE alternating induction chemotherapy. In the 33 evaluable patients we observed an objective response rate of 21.2% and 3% complete response; median survival was 4 months with 2 patients alive 18 months from starting salvage chemotherapy. The treatment was well tolerated. CCNU and methotrexate has shown to be a moderately active and tolerable salvage treatment for small cell lung cancer after CAV/PE alternating first-line chemotherapy.
AB - CCNU and methotrexate were employed as salvage treatment in 34 small cell lung cancer patients resistant to CAV/PE alternating induction chemotherapy. In the 33 evaluable patients we observed an objective response rate of 21.2% and 3% complete response; median survival was 4 months with 2 patients alive 18 months from starting salvage chemotherapy. The treatment was well tolerated. CCNU and methotrexate has shown to be a moderately active and tolerable salvage treatment for small cell lung cancer after CAV/PE alternating first-line chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=0026350064&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026350064&partnerID=8YFLogxK
M3 - Article
C2 - 1666468
AN - SCOPUS:0026350064
VL - 77
SP - 506
EP - 510
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 6
ER -