Salvage chemotherapy with CCNU and methotrexate for small cell lung cancer resistant to CAV/PE alternating chemotherapy

C. Gridelli, A. Contegiacomo, R. Lauria, M. Gentile, G. Airoma, S. De Placido, F. Perrone, G. Ferrante, A. R. Bianco

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

CCNU and methotrexate were employed as salvage treatment in 34 small cell lung cancer patients resistant to CAV/PE alternating induction chemotherapy. In the 33 evaluable patients we observed an objective response rate of 21.2% and 3% complete response; median survival was 4 months with 2 patients alive 18 months from starting salvage chemotherapy. The treatment was well tolerated. CCNU and methotrexate has shown to be a moderately active and tolerable salvage treatment for small cell lung cancer after CAV/PE alternating first-line chemotherapy.

Original languageEnglish
Pages (from-to)506-510
Number of pages5
JournalTumori
Volume77
Issue number6
Publication statusPublished - 1991

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Lomustine
Small Cell Lung Carcinoma
Methotrexate
Salvage Therapy
Drug Therapy
Induction Chemotherapy
Survival
Therapeutics

ASJC Scopus subject areas

  • Cancer Research

Cite this

Gridelli, C., Contegiacomo, A., Lauria, R., Gentile, M., Airoma, G., De Placido, S., ... Bianco, A. R. (1991). Salvage chemotherapy with CCNU and methotrexate for small cell lung cancer resistant to CAV/PE alternating chemotherapy. Tumori, 77(6), 506-510.

Salvage chemotherapy with CCNU and methotrexate for small cell lung cancer resistant to CAV/PE alternating chemotherapy. / Gridelli, C.; Contegiacomo, A.; Lauria, R.; Gentile, M.; Airoma, G.; De Placido, S.; Perrone, F.; Ferrante, G.; Bianco, A. R.

In: Tumori, Vol. 77, No. 6, 1991, p. 506-510.

Research output: Contribution to journalArticle

Gridelli, C, Contegiacomo, A, Lauria, R, Gentile, M, Airoma, G, De Placido, S, Perrone, F, Ferrante, G & Bianco, AR 1991, 'Salvage chemotherapy with CCNU and methotrexate for small cell lung cancer resistant to CAV/PE alternating chemotherapy', Tumori, vol. 77, no. 6, pp. 506-510.
Gridelli C, Contegiacomo A, Lauria R, Gentile M, Airoma G, De Placido S et al. Salvage chemotherapy with CCNU and methotrexate for small cell lung cancer resistant to CAV/PE alternating chemotherapy. Tumori. 1991;77(6):506-510.
Gridelli, C. ; Contegiacomo, A. ; Lauria, R. ; Gentile, M. ; Airoma, G. ; De Placido, S. ; Perrone, F. ; Ferrante, G. ; Bianco, A. R. / Salvage chemotherapy with CCNU and methotrexate for small cell lung cancer resistant to CAV/PE alternating chemotherapy. In: Tumori. 1991 ; Vol. 77, No. 6. pp. 506-510.
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AU - Contegiacomo, A.

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AU - Gentile, M.

AU - Airoma, G.

AU - De Placido, S.

AU - Perrone, F.

AU - Ferrante, G.

AU - Bianco, A. R.

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