Salvage Islet Auto Transplantation After Relaparatomy

G Balzano, R Nano, P Maffi, A Mercalli, R Melzi, F Aleotti, F Gavazzi, C Berra, F de Cobelli, Massimo Venturini, P Magistretti, M Scavini, G Capretti, A Del Maschio, A Secchi, A Zerbi, M Falconi, L Piemonti

Research output: Contribution to journalArticle

Abstract

BACKGROUND: To assess feasibility, safety and metabolic outcome of islet auto transplantation (IAT) in patients undergoing completion pancreatectomy because of sepsis or bleeding following pancreatic surgery. METHODS: From November 2008 to October 2016, 22 patients were candidates to salvage IAT during emergency relaparotomy because of postpancreatectomy sepsis (n=11) or bleeding (n=11). Feasibility, efficacy, and safety of salvage IAT were compared to those documented in a cohort of 36 patients who were candidate to simultaneous IAT during nonemergency preemptive completion pancreatectomy through the pancreaticoduodenectomy. RESULTS: The percentage of candidates that received the infusion of islets was significantly lower in salvage IAT than simultaneous IAT (59.1% vs 88.9%; p=0.008), mainly due to a higher rate of inadequate islet preparations. Even if microbial contamination of islet preparation was significantly higher in candidates to salvage IAT than in those to simultaneous IAT (78.9% vs 20%, p
Original languageEnglish
Pages (from-to)2492-2500
Number of pages9
JournalTransplantation
Volume101
Issue number10
DOIs
Publication statusPublished - 2017

Fingerprint

Islets of Langerhans Transplantation
Pancreatectomy
Sepsis
Hemorrhage
Safety
Pancreaticoduodenectomy
Emergencies

Cite this

Salvage Islet Auto Transplantation After Relaparatomy. / Balzano, G; Nano, R; Maffi, P; Mercalli, A; Melzi, R; Aleotti, F; Gavazzi, F; Berra, C; de Cobelli, F; Venturini, Massimo; Magistretti, P; Scavini, M; Capretti, G; Del Maschio, A; Secchi, A; Zerbi, A; Falconi, M; Piemonti, L.

In: Transplantation, Vol. 101, No. 10, 2017, p. 2492-2500.

Research output: Contribution to journalArticle

@article{58e7fd5a0c6547369926e0062d7d92c8,
title = "Salvage Islet Auto Transplantation After Relaparatomy",
abstract = "BACKGROUND: To assess feasibility, safety and metabolic outcome of islet auto transplantation (IAT) in patients undergoing completion pancreatectomy because of sepsis or bleeding following pancreatic surgery. METHODS: From November 2008 to October 2016, 22 patients were candidates to salvage IAT during emergency relaparotomy because of postpancreatectomy sepsis (n=11) or bleeding (n=11). Feasibility, efficacy, and safety of salvage IAT were compared to those documented in a cohort of 36 patients who were candidate to simultaneous IAT during nonemergency preemptive completion pancreatectomy through the pancreaticoduodenectomy. RESULTS: The percentage of candidates that received the infusion of islets was significantly lower in salvage IAT than simultaneous IAT (59.1{\%} vs 88.9{\%}; p=0.008), mainly due to a higher rate of inadequate islet preparations. Even if microbial contamination of islet preparation was significantly higher in candidates to salvage IAT than in those to simultaneous IAT (78.9{\%} vs 20{\%}, p",
author = "G Balzano and R Nano and P Maffi and A Mercalli and R Melzi and F Aleotti and F Gavazzi and C Berra and {de Cobelli}, F and Massimo Venturini and P Magistretti and M Scavini and G Capretti and {Del Maschio}, A and A Secchi and A Zerbi and M Falconi and L Piemonti",
year = "2017",
doi = "10.1097/TP.0000000000001750",
language = "English",
volume = "101",
pages = "2492--2500",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Salvage Islet Auto Transplantation After Relaparatomy

AU - Balzano, G

AU - Nano, R

AU - Maffi, P

AU - Mercalli, A

AU - Melzi, R

AU - Aleotti, F

AU - Gavazzi, F

AU - Berra, C

AU - de Cobelli, F

AU - Venturini, Massimo

AU - Magistretti, P

AU - Scavini, M

AU - Capretti, G

AU - Del Maschio, A

AU - Secchi, A

AU - Zerbi, A

AU - Falconi, M

AU - Piemonti, L

PY - 2017

Y1 - 2017

N2 - BACKGROUND: To assess feasibility, safety and metabolic outcome of islet auto transplantation (IAT) in patients undergoing completion pancreatectomy because of sepsis or bleeding following pancreatic surgery. METHODS: From November 2008 to October 2016, 22 patients were candidates to salvage IAT during emergency relaparotomy because of postpancreatectomy sepsis (n=11) or bleeding (n=11). Feasibility, efficacy, and safety of salvage IAT were compared to those documented in a cohort of 36 patients who were candidate to simultaneous IAT during nonemergency preemptive completion pancreatectomy through the pancreaticoduodenectomy. RESULTS: The percentage of candidates that received the infusion of islets was significantly lower in salvage IAT than simultaneous IAT (59.1% vs 88.9%; p=0.008), mainly due to a higher rate of inadequate islet preparations. Even if microbial contamination of islet preparation was significantly higher in candidates to salvage IAT than in those to simultaneous IAT (78.9% vs 20%, p

AB - BACKGROUND: To assess feasibility, safety and metabolic outcome of islet auto transplantation (IAT) in patients undergoing completion pancreatectomy because of sepsis or bleeding following pancreatic surgery. METHODS: From November 2008 to October 2016, 22 patients were candidates to salvage IAT during emergency relaparotomy because of postpancreatectomy sepsis (n=11) or bleeding (n=11). Feasibility, efficacy, and safety of salvage IAT were compared to those documented in a cohort of 36 patients who were candidate to simultaneous IAT during nonemergency preemptive completion pancreatectomy through the pancreaticoduodenectomy. RESULTS: The percentage of candidates that received the infusion of islets was significantly lower in salvage IAT than simultaneous IAT (59.1% vs 88.9%; p=0.008), mainly due to a higher rate of inadequate islet preparations. Even if microbial contamination of islet preparation was significantly higher in candidates to salvage IAT than in those to simultaneous IAT (78.9% vs 20%, p

U2 - 10.1097/TP.0000000000001750

DO - 10.1097/TP.0000000000001750

M3 - Article

VL - 101

SP - 2492

EP - 2500

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 10

ER -