Salvage Islet Auto Transplantation After Relaparatomy

G Balzano, R Nano, P Maffi, A Mercalli, R Melzi, F Aleotti, F Gavazzi, C Berra, F de Cobelli, Massimo Venturini, P Magistretti, M Scavini, G Capretti, A Del Maschio, A Secchi, A Zerbi, M Falconi, L Piemonti

Research output: Contribution to journalArticle

Abstract

BACKGROUND: To assess feasibility, safety and metabolic outcome of islet auto transplantation (IAT) in patients undergoing completion pancreatectomy because of sepsis or bleeding following pancreatic surgery. METHODS: From November 2008 to October 2016, 22 patients were candidates to salvage IAT during emergency relaparotomy because of postpancreatectomy sepsis (n=11) or bleeding (n=11). Feasibility, efficacy, and safety of salvage IAT were compared to those documented in a cohort of 36 patients who were candidate to simultaneous IAT during nonemergency preemptive completion pancreatectomy through the pancreaticoduodenectomy. RESULTS: The percentage of candidates that received the infusion of islets was significantly lower in salvage IAT than simultaneous IAT (59.1% vs 88.9%; p=0.008), mainly due to a higher rate of inadequate islet preparations. Even if microbial contamination of islet preparation was significantly higher in candidates to salvage IAT than in those to simultaneous IAT (78.9% vs 20%, p
Original languageEnglish
Pages (from-to)2492-2500
Number of pages9
JournalTransplantation
Volume101
Issue number10
DOIs
Publication statusPublished - 2017

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