Salvage photodynamic therapy for recurrent nasopharyngeal carcinoma

Giovanni Succo, S. Rosso, G. L. Fadda, M. Fantini, Erika Crosetti

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: To evaluate the feasibility of photodynamic therapy (NP-PDT) in the palliative management of recurrent/persistent nasopharyngeal cancer (NFC). Methods: Six patients with persistent/recurrent NPC underwent PDT with palliative intent. NP-PDT was delivered by three different methods depending on the localization, size and depth of the lesion: type I NP-PDT: transnasal direct illumination of postero-superior recurrence; type II NP-PDT: transnasal direct illumination of the whole nasopharynx; type III NP-PDT: transoral direct or interstitial illumination of lateral recurrence. In this case, the ENT-magnetic navigation system (MNS) was extremely useful in identifying the tumor and its distance from the ICA. Results: Both patients treated with NP-PDT type I are free from disease at 38 and 71 months after treatment; both patients treated with NP-PDT type II experienced further local and loco-regional recurrence of disease within 16 months; one died of the disease while the second underwent a second palliative treatment, NP-PDT type I, and is currently living with the disease; of the two patients who underwent NP-PDT type III, one died as a result of regional and systemic recurrence without local recurrence while the second experienced a superficial recurrence. He underwent a second NP-PDT type III treatment and is currently free from disease at 21 months. Conclusions: NP-PDT is a non-invasive and simple treatment modality that may have an important role in the treatment of selected cases of persistent/recurrent NPC in its early stage, not suitable for a conventional therapeutic protocol. Coupling NP-PDT with the ENT-MNS can be an effective strategy to obtain more precise light delivery within the tumor, particularly in lateral and parapharyngeal localization.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalPhotodiagnosis and Photodynamic Therapy
Volume11
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Salvage Therapy
Photochemotherapy
Recurrence
Lighting
1-phenyl-3,3-dimethyltriazene
Nasopharyngeal carcinoma
Nasopharyngeal Neoplasms
Therapeutics
Nasopharynx
Palliative Care
Neoplasms

Keywords

  • Magnetic
  • Nasopharyngeal cancer
  • Neuronavigator
  • Photodynamic therapy
  • Recurrence

ASJC Scopus subject areas

  • Biophysics
  • Oncology
  • Dermatology
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Salvage photodynamic therapy for recurrent nasopharyngeal carcinoma. / Succo, Giovanni; Rosso, S.; Fadda, G. L.; Fantini, M.; Crosetti, Erika.

In: Photodiagnosis and Photodynamic Therapy, Vol. 11, No. 2, 2014, p. 63-70.

Research output: Contribution to journalArticle

@article{4c5d85878d43472fbfbcad779b1f6621,
title = "Salvage photodynamic therapy for recurrent nasopharyngeal carcinoma",
abstract = "Background: To evaluate the feasibility of photodynamic therapy (NP-PDT) in the palliative management of recurrent/persistent nasopharyngeal cancer (NFC). Methods: Six patients with persistent/recurrent NPC underwent PDT with palliative intent. NP-PDT was delivered by three different methods depending on the localization, size and depth of the lesion: type I NP-PDT: transnasal direct illumination of postero-superior recurrence; type II NP-PDT: transnasal direct illumination of the whole nasopharynx; type III NP-PDT: transoral direct or interstitial illumination of lateral recurrence. In this case, the ENT-magnetic navigation system (MNS) was extremely useful in identifying the tumor and its distance from the ICA. Results: Both patients treated with NP-PDT type I are free from disease at 38 and 71 months after treatment; both patients treated with NP-PDT type II experienced further local and loco-regional recurrence of disease within 16 months; one died of the disease while the second underwent a second palliative treatment, NP-PDT type I, and is currently living with the disease; of the two patients who underwent NP-PDT type III, one died as a result of regional and systemic recurrence without local recurrence while the second experienced a superficial recurrence. He underwent a second NP-PDT type III treatment and is currently free from disease at 21 months. Conclusions: NP-PDT is a non-invasive and simple treatment modality that may have an important role in the treatment of selected cases of persistent/recurrent NPC in its early stage, not suitable for a conventional therapeutic protocol. Coupling NP-PDT with the ENT-MNS can be an effective strategy to obtain more precise light delivery within the tumor, particularly in lateral and parapharyngeal localization.",
keywords = "Magnetic, Nasopharyngeal cancer, Neuronavigator, Photodynamic therapy, Recurrence",
author = "Giovanni Succo and S. Rosso and Fadda, {G. L.} and M. Fantini and Erika Crosetti",
year = "2014",
doi = "10.1016/j.pdpdt.2014.01.004",
language = "English",
volume = "11",
pages = "63--70",
journal = "Photodiagnosis and Photodynamic Therapy",
issn = "1572-1000",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Salvage photodynamic therapy for recurrent nasopharyngeal carcinoma

AU - Succo, Giovanni

AU - Rosso, S.

AU - Fadda, G. L.

AU - Fantini, M.

AU - Crosetti, Erika

PY - 2014

Y1 - 2014

N2 - Background: To evaluate the feasibility of photodynamic therapy (NP-PDT) in the palliative management of recurrent/persistent nasopharyngeal cancer (NFC). Methods: Six patients with persistent/recurrent NPC underwent PDT with palliative intent. NP-PDT was delivered by three different methods depending on the localization, size and depth of the lesion: type I NP-PDT: transnasal direct illumination of postero-superior recurrence; type II NP-PDT: transnasal direct illumination of the whole nasopharynx; type III NP-PDT: transoral direct or interstitial illumination of lateral recurrence. In this case, the ENT-magnetic navigation system (MNS) was extremely useful in identifying the tumor and its distance from the ICA. Results: Both patients treated with NP-PDT type I are free from disease at 38 and 71 months after treatment; both patients treated with NP-PDT type II experienced further local and loco-regional recurrence of disease within 16 months; one died of the disease while the second underwent a second palliative treatment, NP-PDT type I, and is currently living with the disease; of the two patients who underwent NP-PDT type III, one died as a result of regional and systemic recurrence without local recurrence while the second experienced a superficial recurrence. He underwent a second NP-PDT type III treatment and is currently free from disease at 21 months. Conclusions: NP-PDT is a non-invasive and simple treatment modality that may have an important role in the treatment of selected cases of persistent/recurrent NPC in its early stage, not suitable for a conventional therapeutic protocol. Coupling NP-PDT with the ENT-MNS can be an effective strategy to obtain more precise light delivery within the tumor, particularly in lateral and parapharyngeal localization.

AB - Background: To evaluate the feasibility of photodynamic therapy (NP-PDT) in the palliative management of recurrent/persistent nasopharyngeal cancer (NFC). Methods: Six patients with persistent/recurrent NPC underwent PDT with palliative intent. NP-PDT was delivered by three different methods depending on the localization, size and depth of the lesion: type I NP-PDT: transnasal direct illumination of postero-superior recurrence; type II NP-PDT: transnasal direct illumination of the whole nasopharynx; type III NP-PDT: transoral direct or interstitial illumination of lateral recurrence. In this case, the ENT-magnetic navigation system (MNS) was extremely useful in identifying the tumor and its distance from the ICA. Results: Both patients treated with NP-PDT type I are free from disease at 38 and 71 months after treatment; both patients treated with NP-PDT type II experienced further local and loco-regional recurrence of disease within 16 months; one died of the disease while the second underwent a second palliative treatment, NP-PDT type I, and is currently living with the disease; of the two patients who underwent NP-PDT type III, one died as a result of regional and systemic recurrence without local recurrence while the second experienced a superficial recurrence. He underwent a second NP-PDT type III treatment and is currently free from disease at 21 months. Conclusions: NP-PDT is a non-invasive and simple treatment modality that may have an important role in the treatment of selected cases of persistent/recurrent NPC in its early stage, not suitable for a conventional therapeutic protocol. Coupling NP-PDT with the ENT-MNS can be an effective strategy to obtain more precise light delivery within the tumor, particularly in lateral and parapharyngeal localization.

KW - Magnetic

KW - Nasopharyngeal cancer

KW - Neuronavigator

KW - Photodynamic therapy

KW - Recurrence

UR - http://www.scopus.com/inward/record.url?scp=84901628206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901628206&partnerID=8YFLogxK

U2 - 10.1016/j.pdpdt.2014.01.004

DO - 10.1016/j.pdpdt.2014.01.004

M3 - Article

VL - 11

SP - 63

EP - 70

JO - Photodiagnosis and Photodynamic Therapy

JF - Photodiagnosis and Photodynamic Therapy

SN - 1572-1000

IS - 2

ER -