Abstract
To evaluate how aging and estrogen deficiency influence the success rate of Sandblasted Titanium (Ti/SA) implants, the osteointegration of Ti/SA rods was studied in the cortical and trabecular bone of 5 young, 5 aged and 5 ovariectomized (OVX) sheep. The characterization of the host bone by transiliac biopsies of the iliac crest showed a progressive rarefaction of trabecular bone in aged and OVX animals when compared to young ones. A significant reduction, both in cortical and trabecular bone, of the osteointegration rate of Ti/SA rods in the presence of estrogen deficiency compared to young animals was observed, while only a minor reduction was observed in aged animals. These results were confirmed by the pushout test in cortical bone. Bone quality affected the biological response of bone to Ti/SA implants in both trabecular and cortical bone; consequently, strategies to maximize the bone osteogenic properties of osteoporotic patients should be adopted.
| Original language | English |
|---|---|
| Pages (from-to) | 163-172 |
| Number of pages | 10 |
| Journal | International Journal of Artificial Organs |
| Volume | 30 |
| Issue number | 2 |
| Publication status | Published - Feb 2007 |
Keywords
- Aging
- Osteointegration
- Osteoporosis
- Sanblasted titanium
- Sheep model
ASJC Scopus subject areas
- Biophysics