Sandblasted titanium osteointegration in young, aged and ovariectomized sheep

V. Borsari, Milena Fini, G. Giavaresi, L. Rimondini, R. Chiesa, L. Chiusoli, R. Giardino

Research output: Contribution to journalArticlepeer-review


To evaluate how aging and estrogen deficiency influence the success rate of Sandblasted Titanium (Ti/SA) implants, the osteointegration of Ti/SA rods was studied in the cortical and trabecular bone of 5 young, 5 aged and 5 ovariectomized (OVX) sheep. The characterization of the host bone by transiliac biopsies of the iliac crest showed a progressive rarefaction of trabecular bone in aged and OVX animals when compared to young ones. A significant reduction, both in cortical and trabecular bone, of the osteointegration rate of Ti/SA rods in the presence of estrogen deficiency compared to young animals was observed, while only a minor reduction was observed in aged animals. These results were confirmed by the pushout test in cortical bone. Bone quality affected the biological response of bone to Ti/SA implants in both trabecular and cortical bone; consequently, strategies to maximize the bone osteogenic properties of osteoporotic patients should be adopted.

Original languageEnglish
Pages (from-to)163-172
Number of pages10
JournalInternational Journal of Artificial Organs
Issue number2
Publication statusPublished - Feb 2007


  • Aging
  • Osteointegration
  • Osteoporosis
  • Sanblasted titanium
  • Sheep model

ASJC Scopus subject areas

  • Biophysics


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