Sarcoid-like reaction in breast cancer: A long-term follow-up series of eight patients

Stefano Martella, Visnu Lohsiriwat, Daniel Meirelles Barbalho, Paolo Della Vigna, Luca Bottiglieri, Tito Brambullo, Alessandra Gottardi, Mario Rietjens, Jean Yves Petit

Research output: Contribution to journalArticlepeer-review


Purpose: Finding an intrathoracic or axillary mass in a breast cancer patient should raise suspicion of a pulmonary or mediastinal nodal metastasis or axillary recurrence. Surprisingly, noncaseating epithelioid cell granuloma can be found in this type of lesion, as in sarcoidosis or a sarcoid-like reaction. Methods: This series included eight breast cancer patients in whom a late sarcoid-like reaction developed: as an intrathoracic lesion in six, and as an ipsilateral axillary lesion in two. The latency period from oncological surgery to the diagnosis of sarcoidosis was 40 months and the average follow-up after the diagnosis of sarcoidosis was 63.38 months. Results: None of the patients suffered relapse or oncological events during the period of this study. Conclusion: To avoid misdiagnosis and overtreatment, pathological examination should always be carried out. We do not recommend any specific treatment for sarcoidosis in a breast cancer patient, but routine oncological follow-up is appropriate. A larger series with statistical analysis is necessary to evaluate the prognosis.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalSurgery Today
Issue number3
Publication statusPublished - Feb 2012


  • Breast cancer
  • Metastasis
  • Recurrence
  • Sarcoid-like reaction
  • Sarcoidosis

ASJC Scopus subject areas

  • Surgery


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