Sarcoidosis in a patient with 5q-myelodysplasia. A possible pathogenetic link between the two diseases

L. Airaghi, D. Montori, F. Zorzi, A. Miadonna, A. Tedeschi

Research output: Contribution to journalArticlepeer-review

Abstract

This study describes the occurrence of sarcoidosis with lung and skin involvement in a 56-yr-old woman who suffered from 5q-myelodysplastic syndrome since the age of 50. The 5q-myelodysplastic syndrome is marked by deletion of the long arm of chromosome 5, which carries the genes coding for T-helper cell 2 cytokines, such as interleukins-3, -4 and -5, and granulocyte-macrophage colony-stimulating factor. Although the aetiology of sarcoidosis remains unclear, sarcoid granulomatous inflammation is marked by predominant expression of T-helper cell 1 cytokines, with reduced expression of T-helper cell 2 cytokines. The authors suggest that 5q-abnormality may have pre-disposed to sarcoidosis through an imbalance in the cytokine network, caused by the deletion of genes coding for T-helper cell 2 cytokines.

Original languageEnglish
Pages (from-to)378-380
Number of pages3
JournalMonaldi Archives for Chest Disease - Cardiac Series
Volume55
Issue number5
Publication statusPublished - 2000

Keywords

  • 5q-syndrome
  • Myelodysplasia
  • Sarcoidosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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