Sarcoidosis in an Italian province. Prevalence and environmental risk factors

Deborah Beghè, Luca Dall'Asta, Claudia Garavelli, Augusto Alberto Pastorelli, Marilena Muscarella, Gloria Saccani, Marina Aiello, Ernesto Crisafulli, Massimo Corradi, Paolo Stacchini, Alfredo Chetta, Giuseppina Bertorelli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background and aim: Sarcoidosis is a systemic granulomatous inflammatory disease whose causes are still unknown and for which epidemiological data are often discordant. The aim of our study is to investigate prevalence and spatial distribution of cases, and identify environmental exposures associated with sarcoidosis in an Italian province. Methods: After georeferentiation of cases, the area under study was subdivided with respect to Municipality and Health Districts and to the altitude in order to identify zonal differences in prevalence. The bioaccumulation levels of 12 metals in lichen tissues were analyzed, in order to determine sources of air pollution. Finally, the analysis of the correlation between metals and between pickup stations was performed. Results: 223 patients were identified (58.3% female and 41.7% male of total) and the mean age was 50.6-15.4 years (53.5-15.5 years for the females and 46.5-14.4 for the males). The mean prevalence was 49 per 100.000 individuals. However, we observed very heterogeneous prevalence in the area under study. The correlations among metals revealed different deposition patterns in lowland area respect to hilly and mountain areas. Conclusions: The study highlights a high prevalence of sarcoidosis cases, characterized by a very inhomogeneous and patchy distribution with phenomena of local aggregation. Moreover, the bioaccumulation analysis was an effective method to identify the mineral particles that mostly contribute to air pollution in the different areas, but it was not sufficient to establish a clear correlation between the onset of sarcoidosis and environmental risk factors.

Original languageEnglish
Article numbere0176859
JournalPLoS One
Volume12
Issue number5
DOIs
Publication statusPublished - May 1 2017

Fingerprint

Sarcoidosis
Bioaccumulation
risk factors
Metals
Air pollution
Air Pollution
metals
air pollution
bioaccumulation
Pickups
Spatial distribution
Particles (particulate matter)
Minerals
Agglomeration
Lichens
Health
Tissue
Environmental Exposure
lichens
lowlands

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Beghè, D., Dall'Asta, L., Garavelli, C., Pastorelli, A. A., Muscarella, M., Saccani, G., ... Bertorelli, G. (2017). Sarcoidosis in an Italian province. Prevalence and environmental risk factors. PLoS One, 12(5), [e0176859]. https://doi.org/10.1371/journal.pone.0176859

Sarcoidosis in an Italian province. Prevalence and environmental risk factors. / Beghè, Deborah; Dall'Asta, Luca; Garavelli, Claudia; Pastorelli, Augusto Alberto; Muscarella, Marilena; Saccani, Gloria; Aiello, Marina; Crisafulli, Ernesto; Corradi, Massimo; Stacchini, Paolo; Chetta, Alfredo; Bertorelli, Giuseppina.

In: PLoS One, Vol. 12, No. 5, e0176859, 01.05.2017.

Research output: Contribution to journalArticle

Beghè, D, Dall'Asta, L, Garavelli, C, Pastorelli, AA, Muscarella, M, Saccani, G, Aiello, M, Crisafulli, E, Corradi, M, Stacchini, P, Chetta, A & Bertorelli, G 2017, 'Sarcoidosis in an Italian province. Prevalence and environmental risk factors', PLoS One, vol. 12, no. 5, e0176859. https://doi.org/10.1371/journal.pone.0176859
Beghè D, Dall'Asta L, Garavelli C, Pastorelli AA, Muscarella M, Saccani G et al. Sarcoidosis in an Italian province. Prevalence and environmental risk factors. PLoS One. 2017 May 1;12(5). e0176859. https://doi.org/10.1371/journal.pone.0176859
Beghè, Deborah ; Dall'Asta, Luca ; Garavelli, Claudia ; Pastorelli, Augusto Alberto ; Muscarella, Marilena ; Saccani, Gloria ; Aiello, Marina ; Crisafulli, Ernesto ; Corradi, Massimo ; Stacchini, Paolo ; Chetta, Alfredo ; Bertorelli, Giuseppina. / Sarcoidosis in an Italian province. Prevalence and environmental risk factors. In: PLoS One. 2017 ; Vol. 12, No. 5.
@article{3e3c947738ff445e89e8caeeb18f4c7e,
title = "Sarcoidosis in an Italian province. Prevalence and environmental risk factors",
abstract = "Background and aim: Sarcoidosis is a systemic granulomatous inflammatory disease whose causes are still unknown and for which epidemiological data are often discordant. The aim of our study is to investigate prevalence and spatial distribution of cases, and identify environmental exposures associated with sarcoidosis in an Italian province. Methods: After georeferentiation of cases, the area under study was subdivided with respect to Municipality and Health Districts and to the altitude in order to identify zonal differences in prevalence. The bioaccumulation levels of 12 metals in lichen tissues were analyzed, in order to determine sources of air pollution. Finally, the analysis of the correlation between metals and between pickup stations was performed. Results: 223 patients were identified (58.3{\%} female and 41.7{\%} male of total) and the mean age was 50.6-15.4 years (53.5-15.5 years for the females and 46.5-14.4 for the males). The mean prevalence was 49 per 100.000 individuals. However, we observed very heterogeneous prevalence in the area under study. The correlations among metals revealed different deposition patterns in lowland area respect to hilly and mountain areas. Conclusions: The study highlights a high prevalence of sarcoidosis cases, characterized by a very inhomogeneous and patchy distribution with phenomena of local aggregation. Moreover, the bioaccumulation analysis was an effective method to identify the mineral particles that mostly contribute to air pollution in the different areas, but it was not sufficient to establish a clear correlation between the onset of sarcoidosis and environmental risk factors.",
author = "Deborah Begh{\`e} and Luca Dall'Asta and Claudia Garavelli and Pastorelli, {Augusto Alberto} and Marilena Muscarella and Gloria Saccani and Marina Aiello and Ernesto Crisafulli and Massimo Corradi and Paolo Stacchini and Alfredo Chetta and Giuseppina Bertorelli",
year = "2017",
month = "5",
day = "1",
doi = "10.1371/journal.pone.0176859",
language = "English",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

TY - JOUR

T1 - Sarcoidosis in an Italian province. Prevalence and environmental risk factors

AU - Beghè, Deborah

AU - Dall'Asta, Luca

AU - Garavelli, Claudia

AU - Pastorelli, Augusto Alberto

AU - Muscarella, Marilena

AU - Saccani, Gloria

AU - Aiello, Marina

AU - Crisafulli, Ernesto

AU - Corradi, Massimo

AU - Stacchini, Paolo

AU - Chetta, Alfredo

AU - Bertorelli, Giuseppina

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background and aim: Sarcoidosis is a systemic granulomatous inflammatory disease whose causes are still unknown and for which epidemiological data are often discordant. The aim of our study is to investigate prevalence and spatial distribution of cases, and identify environmental exposures associated with sarcoidosis in an Italian province. Methods: After georeferentiation of cases, the area under study was subdivided with respect to Municipality and Health Districts and to the altitude in order to identify zonal differences in prevalence. The bioaccumulation levels of 12 metals in lichen tissues were analyzed, in order to determine sources of air pollution. Finally, the analysis of the correlation between metals and between pickup stations was performed. Results: 223 patients were identified (58.3% female and 41.7% male of total) and the mean age was 50.6-15.4 years (53.5-15.5 years for the females and 46.5-14.4 for the males). The mean prevalence was 49 per 100.000 individuals. However, we observed very heterogeneous prevalence in the area under study. The correlations among metals revealed different deposition patterns in lowland area respect to hilly and mountain areas. Conclusions: The study highlights a high prevalence of sarcoidosis cases, characterized by a very inhomogeneous and patchy distribution with phenomena of local aggregation. Moreover, the bioaccumulation analysis was an effective method to identify the mineral particles that mostly contribute to air pollution in the different areas, but it was not sufficient to establish a clear correlation between the onset of sarcoidosis and environmental risk factors.

AB - Background and aim: Sarcoidosis is a systemic granulomatous inflammatory disease whose causes are still unknown and for which epidemiological data are often discordant. The aim of our study is to investigate prevalence and spatial distribution of cases, and identify environmental exposures associated with sarcoidosis in an Italian province. Methods: After georeferentiation of cases, the area under study was subdivided with respect to Municipality and Health Districts and to the altitude in order to identify zonal differences in prevalence. The bioaccumulation levels of 12 metals in lichen tissues were analyzed, in order to determine sources of air pollution. Finally, the analysis of the correlation between metals and between pickup stations was performed. Results: 223 patients were identified (58.3% female and 41.7% male of total) and the mean age was 50.6-15.4 years (53.5-15.5 years for the females and 46.5-14.4 for the males). The mean prevalence was 49 per 100.000 individuals. However, we observed very heterogeneous prevalence in the area under study. The correlations among metals revealed different deposition patterns in lowland area respect to hilly and mountain areas. Conclusions: The study highlights a high prevalence of sarcoidosis cases, characterized by a very inhomogeneous and patchy distribution with phenomena of local aggregation. Moreover, the bioaccumulation analysis was an effective method to identify the mineral particles that mostly contribute to air pollution in the different areas, but it was not sufficient to establish a clear correlation between the onset of sarcoidosis and environmental risk factors.

UR - http://www.scopus.com/inward/record.url?scp=85019128428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019128428&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0176859

DO - 10.1371/journal.pone.0176859

M3 - Article

VL - 12

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e0176859

ER -