Sarcoidosis mimicking metastatic gynaecological malignancies: A diagnostic and therapeutic challenge?

P. Mapelli, G. Mangili, M. Picchio, E. Rabaiotti, L. Gianolli, C. Messa, M. Candiani

Research output: Contribution to journalArticlepeer-review


Several case reports describing the coexistence of sarcoidosis and malignancy have been published. Therefore, sarcoidosis should always be considered as a differential diagnosis when a cancer patient develops lymphadenopathy. Positron-emission tomography (PET) 2-[18F]-fluoro-2-deoxy. d-glucose (FDG) combined with computed tomography (CT) is widely used for cancer staging and surveillance because it permits localization of metabolically active malignant tissue. PET/CT or CT findings in patients with suspected cancer recurrence can be used to guide early and aggressive therapy. However, benign hypermetabolic lymphadenopathy can mimic malignant lymphadenopathy, both on a conventional CT scan and on PET/CT. Thus, it is important to obtain a histological diagnosis before initiating antineoplastic therapy based on imaging findings. Four cases of patients affected by gynaecological malignancies and coexisting sarcoidosis are reported in this study. Furthermore, the clinical relevance of making a differential diagnosis between gynaecological cancer recurrence and granulomatous disorder is given specific mention.

Original languageEnglish
Pages (from-to)314-317
Number of pages4
JournalRevista Espanola de Medicina Nuclear e Imagen Molecular
Issue number5
Publication statusPublished - Sep 2013


  • Gynaecological malignancies
  • PET/CT false positive
  • Sarcoidosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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