Sarcoma

Concordance between initial diagnosis and centralized expert review in a population-based study within three European regions

I. Ray-coquard, M. C. Montesco, J. M. Coindre, A. P. Dei tos, A. Lurkin, D. Ranchère-vince, A. Vecchiato, A. V. Decouvelaere, S. Mathoulin-pélissier, S. Albert, P. Cousin, D. Cellier, L. Toffolatti, C. R. Rossi, J. Y. Blay

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Background: Sarcomas represent a heterogeneous group of tumors. Accurate determination of histological diagnosis and prognostic factors is critical for the delineation of treatment strategies. The contribution of second opinion (SO) to improve diagnostic accuracy has been suggested for sarcoma but has never been established in population-based studies. Methods: Histological data of patients diagnosed with sarcoma in Rhone-Alpes (France), Veneto (Italy) and Aquitaine (France) over a 2-year period were collected. Initial diagnoses were systematically compared with SO from regional and national experts. Results: Of 2016 selected patients, 1463 (73%) matched the inclusion criteria and were analyzed. Full concordance between primary diagnosis and SO (the first pathologist and the expert reached identical conclusions) was observed in 824 (56%) cases, partial concordance (identical diagnosis of connective tumor but different grade or histological subtype) in 518 (35%) cases and complete discordance (benign versus malignant, different histological type or invalidation of the diagnosis of sarcoma) in 121 (8%) cases. The major discrepancies were related to histological grade (n = 274, 43%), histological type (n = 144, 24%), subtype (n = 18, 3%) and grade plus subtype or grade plus histological type (n = 178, 29%). Conclusion: More than 40% of first histological diagnoses were modified at second reading, possibly resulting in different treatment decisions.

Original languageEnglish
Article numbermdr610
Pages (from-to)2442-2449
Number of pages8
JournalAnnals of Oncology
Volume23
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Sarcoma
Population
Referral and Consultation
France
Italy
Reading
Neoplasms
Therapeutics

Keywords

  • Concordance evaluation
  • Histological review
  • Medical decision
  • Molecular biology
  • Sarcoma

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Ray-coquard, I., Montesco, M. C., Coindre, J. M., Dei tos, A. P., Lurkin, A., Ranchère-vince, D., ... Blay, J. Y. (2012). Sarcoma: Concordance between initial diagnosis and centralized expert review in a population-based study within three European regions. Annals of Oncology, 23(9), 2442-2449. [mdr610]. https://doi.org/10.1093/annonc/mdr610

Sarcoma : Concordance between initial diagnosis and centralized expert review in a population-based study within three European regions. / Ray-coquard, I.; Montesco, M. C.; Coindre, J. M.; Dei tos, A. P.; Lurkin, A.; Ranchère-vince, D.; Vecchiato, A.; Decouvelaere, A. V.; Mathoulin-pélissier, S.; Albert, S.; Cousin, P.; Cellier, D.; Toffolatti, L.; Rossi, C. R.; Blay, J. Y.

In: Annals of Oncology, Vol. 23, No. 9, mdr610, 09.2012, p. 2442-2449.

Research output: Contribution to journalArticle

Ray-coquard, I, Montesco, MC, Coindre, JM, Dei tos, AP, Lurkin, A, Ranchère-vince, D, Vecchiato, A, Decouvelaere, AV, Mathoulin-pélissier, S, Albert, S, Cousin, P, Cellier, D, Toffolatti, L, Rossi, CR & Blay, JY 2012, 'Sarcoma: Concordance between initial diagnosis and centralized expert review in a population-based study within three European regions', Annals of Oncology, vol. 23, no. 9, mdr610, pp. 2442-2449. https://doi.org/10.1093/annonc/mdr610
Ray-coquard, I. ; Montesco, M. C. ; Coindre, J. M. ; Dei tos, A. P. ; Lurkin, A. ; Ranchère-vince, D. ; Vecchiato, A. ; Decouvelaere, A. V. ; Mathoulin-pélissier, S. ; Albert, S. ; Cousin, P. ; Cellier, D. ; Toffolatti, L. ; Rossi, C. R. ; Blay, J. Y. / Sarcoma : Concordance between initial diagnosis and centralized expert review in a population-based study within three European regions. In: Annals of Oncology. 2012 ; Vol. 23, No. 9. pp. 2442-2449.
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abstract = "Background: Sarcomas represent a heterogeneous group of tumors. Accurate determination of histological diagnosis and prognostic factors is critical for the delineation of treatment strategies. The contribution of second opinion (SO) to improve diagnostic accuracy has been suggested for sarcoma but has never been established in population-based studies. Methods: Histological data of patients diagnosed with sarcoma in Rhone-Alpes (France), Veneto (Italy) and Aquitaine (France) over a 2-year period were collected. Initial diagnoses were systematically compared with SO from regional and national experts. Results: Of 2016 selected patients, 1463 (73{\%}) matched the inclusion criteria and were analyzed. Full concordance between primary diagnosis and SO (the first pathologist and the expert reached identical conclusions) was observed in 824 (56{\%}) cases, partial concordance (identical diagnosis of connective tumor but different grade or histological subtype) in 518 (35{\%}) cases and complete discordance (benign versus malignant, different histological type or invalidation of the diagnosis of sarcoma) in 121 (8{\%}) cases. The major discrepancies were related to histological grade (n = 274, 43{\%}), histological type (n = 144, 24{\%}), subtype (n = 18, 3{\%}) and grade plus subtype or grade plus histological type (n = 178, 29{\%}). Conclusion: More than 40{\%} of first histological diagnoses were modified at second reading, possibly resulting in different treatment decisions.",
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AU - Ray-coquard, I.

AU - Montesco, M. C.

AU - Coindre, J. M.

AU - Dei tos, A. P.

AU - Lurkin, A.

AU - Ranchère-vince, D.

AU - Vecchiato, A.

AU - Decouvelaere, A. V.

AU - Mathoulin-pélissier, S.

AU - Albert, S.

AU - Cousin, P.

AU - Cellier, D.

AU - Toffolatti, L.

AU - Rossi, C. R.

AU - Blay, J. Y.

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