Sarcoma metastatic to the brain: A series of 15 cases

Maurizio Salvati, Luigi Cervoni, Riccardo Caruso, Franco Maria Gagliardi, Roberto Delfini

Research output: Contribution to journalArticlepeer-review


METHODS: We report on 15 patients surgically treated for intraparenchymal brain metastases from sarcoma, including six osteosarcomas, five leiomyosarcomas, two malignant fibrous histiocytomas, and two alveolar soft-part sarcomas (ASPS). RESULTS: Median survival after craniotomy was 9.3 months. Patients with a preoperative Karnofsky performance score of > 70 survived for 12.8 versus 5.3 months for those with a Karnofsky performance score <70 (p = 0.03). Patients with evidence of only lung metastases at the time of surgery (nine cases) survived 8.6 months, which was similar to the 10.4-month survival for patients with disease limited to the brain (p = 0.1). The two patients with alveolar soft-part sarcomas are alive at 15 and 20 months after surgery. CONCLUSION: We conclude that surgery is effective in treating selected patients with sarcoma metastatic to the brain and that patients with metastasis from ASPS may have a relatively good prognosis if they are surgically treated. The complete removal of all brain metastases and a Karnofsky performance score > 70 are associated with a favorable prognosis; the presence of concurrent lung metastases is not a contraindication to surgery.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalSurgical Neurology
Issue number4
Publication statusPublished - Apr 1998


  • Brain metastasis
  • Sarcoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


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