SARS-CoV-2 infection and neonates: a review of evidence and unresolved questions

Carlo Pietrasanta, Andrea Ronchi, Federico Schena, Claudia Ballerini, Lea Testa, Giacomo Artieri, Domenica Mercadante, Fabio Mosca, Lorenza Pugni

Research output: Contribution to journalArticlepeer-review

Abstract

SARS-CoV-2 infection in the neonatal period poses previously unmet challenges to obstetricians and neonatologists, but several key questions are yet to be answered. Few cases of presumed in utero vertical transmission of the virus from infected mothers to fetuses have been reported, but stronger evidence is needed, from larger datasets with multiple biospecimens rigorously analyzed. Whether acquired before or after birth, SARS-CoV-2 infection in neonates can be symptomatic, but our comprehension of neonatal immune response and the subsequent clinical characteristics of COVID-19 in early life are incomplete. Finally, the pandemic challenged several dogmas regarding the management of mother-infant dyads, and again more robust data are needed to support the formulation of evidence-based guidelines. Here, we briefly summarize existing evidence and key unresolved questions about SARS-CoV-2 infection and COVID-19 in the neonatal period.

Original languageEnglish
Pages (from-to)79-81
Number of pages3
JournalPediatric Allergy and Immunology
Volume31
Issue numberS26
DOIs
Publication statusPublished - Nov 2020

Keywords

  • 2019-nCoV
  • COVID-19
  • neonate
  • newborn
  • pregnancy
  • prematurity
  • SARS-CoV-2

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

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