Severe Acute Respiratory Syndrome: La prima malattia trasmissibile del nuovo secolo

Translated title of the contribution: SARS: The first transmissible disease of 21st century

Research output: Contribution to journalArticle

Abstract

The Severe Acute Respiratory Syndrome (SARS) is the first severe and easily transmissible disease to emerge in the 21st century. It is caused by the infection with a coronavirus, a single strand RNA capsulated virus, recently found in a small mammalian, the masked palm civet. It is likely to represent the source of human infection. The first cases of SARS have been reported in the Chinese province of Guangdong and, since then, probable cases have been reported world wide. The clinical picture is characterized by nonspecific symptoms such as fever, cough or dyspnea in patients affected by air-space opacities (unifocal involvement in the 54.6% of cases) or distress respiratory syndrome and linked to a recent exposure to a SARS case or to a travel/residence in an affected area. The empirical therapy is based on broad-spectrum antibiotics, steroids and ribavirin, but susceptibility testing have failed to demonstrate direct anti-viral activity of ribavirin against SARS-related coronavirus in vitro. The exposure to respiratory droplets and the contact with biologic fluids (respiratory and gastrointestinal secretions) represent the most efficient transmission modality of the SARS-related coronavirus. Hand hygiene is the most simple and cost effective measure of infection control to prevent contagion, and the use of airborne, contact and droplet precaution is strictly recommended to all health care workers taking care of such patients. The spread of SARS, to less developed country with limited resource for public health programs, represent the emerging alarming threat in the new global scenario.

Original languageItalian
Pages (from-to)295-303
Number of pages9
JournalRecenti Progressi in Medicina
Volume94
Issue number7-8
Publication statusPublished - Jul 2003

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Severe Acute Respiratory Syndrome
Coronavirus
Ribavirin
Hand Hygiene
Viverridae
RNA Viruses
Infection Control
Infection
Cough
Dyspnea
Developing Countries
Patient Care
Fever
Public Health
Steroids
Air
Anti-Bacterial Agents
Delivery of Health Care
Costs and Cost Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Severe Acute Respiratory Syndrome : La prima malattia trasmissibile del nuovo secolo. / Nicastri, Emanuele; Petrosillo, Nicola; Macrì, Giulia; Ippolito, Giuseppe.

In: Recenti Progressi in Medicina, Vol. 94, No. 7-8, 07.2003, p. 295-303.

Research output: Contribution to journalArticle

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