SBOTE study: Extracorporeal shock wave therapy versus electrical stimulation after botulinum toxin type a injection for post-stroke spasticity-a prospective randomized trial

Andrea Santamato, Angela Notarnicola, Francesco Panza, Maurizio Ranieri, Maria Francesca Micello, Paolo Manganotti, Biagio Moretti, Francesca Fortunato, Serena Filoni, Pietro Fiore

Research output: Contribution to journalArticlepeer-review

Abstract

Research is on-going to identify new methods of biostimulation to increase the effect of botulinum toxin type A (BTX-A) in the treatment of spasticity. The Spasticity treated by Botulinum Toxin and ESWT (SBOTE) study is a prospective, randomized controlled trial assessing the effectiveness of extracorporeal shock wave therapy (ESWT) given immediately after BTX-A injections compared with electrical stimulation (ES) given immediately after BTX-A therapy for the management of focal upper limb spasticity in stroke patients. ES was given for 30 min twice a day for 5 days starting at 5 Hz; ESWT was given once a day for 5 days. At study follow-up, patients treated with BTX-A injections and ESWT showed a statistically greater significance and continuous decrease of spasticity measure (modified Ashworth scale [MAS]: 1.37, 1.75 and 1.58 at 15, 30 and 90 days post-treatment, respectively), of spasms (spasm frequency scale [SFS]: 0.8 and 0.25 at 30 and 90 days post-treatment, respectively) and of pain (visual analogue scale [VAS]: 1.94 and 1.87 at 30 and 90 days, respectively) compared with patients treated with BTX-A injections and ES (MAS: 2.37, 2.18 and 2.18, respectively) (p <0.05) (SFS: 1.5 and 1.06, respectively) (p <0.05) (VAS: 2.44 and 2.69 respectively) (p <0.05). ESWT enhances the effect of BTX-A to a greater extent than ES, probably by modulating rheology of the muscle and neurotransmission at the neuromuscular junction.

Original languageEnglish
Pages (from-to)283-291
Number of pages9
JournalUltrasound in Medicine and Biology
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Botulinum toxin type A
  • Electrical stimulation
  • Extracorporeal shock wave therapy
  • Spasticity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

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