SBRT for prostate cancer: Challenges and features from a physicist prospective

Pietro Mancosu, Stefania Clemente, Valeria Landoni, Ruggero Ruggieri, Filippo Alongi, Marta Scorsetti, Michele Stasi

Research output: Contribution to journalArticlepeer-review


Emerging data are showing the safety and the efficacy of Stereotactic Body Radiation Therapy (SBRT) in prostate cancer management. In this context, the medical physicists are regularly involved to review the appropriateness of the adopted technology and to proactively study new solutions. From the physics point of view there are two major challenges in prostate SBRT: (1) mitigation of geometrical uncertainty and (2) generation of highly conformal dose distributions that maximally spare the OARs. Geometrical uncertainties have to be limited as much as possible in order to avoid the use of large PTV margins. Furthermore, advanced planning and delivery techniques are needed to generate maximally conformal dose distributions. In this non-systematic review the technology and the physics aspects of SBRT for prostate cancer were analyzed. In details, the aims were: (i) to describe the rationale of reducing the number of fractions (i.e. increasing the dose per fraction), (ii) to analyze the features to be accounted for performing an extreme hypo-fractionation scheme (>6-7 Gy), and (iii) to describe technological solutions for treating in a safe way. The analysis of outcomes, toxicities, and other clinical aspects are not object of the present evaluation.

Original languageEnglish
Pages (from-to)479-484
Number of pages6
JournalPhysica Medica
Issue number3
Publication statusPublished - Mar 1 2016


  • Medical physics
  • Prostate
  • SABR
  • SBRT

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)


Dive into the research topics of 'SBRT for prostate cancer: Challenges and features from a physicist prospective'. Together they form a unique fingerprint.

Cite this