Scar Homogenization Versus Limited-Substrate Ablation in Patients With Nonischemic Cardiomyopathy and Ventricular Tachycardia

Yalçın Gökoğlan, Sanghamitra Mohanty, Carola Gianni, Pasquale Santangeli, Chintan Trivedi, Mahmut F Güneş, Rong Bai, Amin Al-Ahmad, Joseph G. Gallinghouse, Rodney Horton, Patrick M Hranitzky, Javier E Sanchez, Salwa Beheiry, Richard Hongo, Dhanunjaya Lakkireddy, Madhu Reddy, Robert A. Schweikert, Antonio Dello Russo, Michela Casella, Claudio TondoJ. David Burkhardt, Sakis Themistoclakis, Luigi Di Biase, Andrea Natale

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standard limited-substrate ablation in patients with post-infarction ventricular tachycardia (VT). Whether such benefit extends to patients with nonischemic cardiomyopathy and scar-related VT is unclear.

OBJECTIVES: The aim of this study was to assess the long-term efficacy of an endoepicardial scar homogenization approach compared with standard ablation in this population.

METHODS: Consecutive patients with dilated nonischemic cardiomyopathy (n = 93), scar-related VTs, and evidence of low-voltage regions on the basis of pre-defined criteria on electroanatomic mapping (i.e., bipolar voltage <1.5 mV) underwent either standard VT ablation (group 1 [n = 57]) or endoepicardial ablation of all abnormal potentials within the electroanatomic scar (group 2 [n = 36]). Acute procedural success was defined as noninducibility of any VT at the end of the procedure; long-term success was defined as freedom from any ventricular arrhythmia at follow-up.

RESULTS: Acute procedural success rates were 69.4% and 42.1% after scar homogenization and standard ablation, respectively (p = 0.01). During a mean follow-up period of 14 ± 2 months, single-procedure success rates were 63.9% after scar homogenization and 38.6% after standard ablation (p = 0.031). After multivariate analysis, scar homogenization and left ventricular ejection fraction were predictors of long-term success. During follow-up, the rehospitalization rate was significantly lower in the scar homogenization group (p = 0.035).

CONCLUSIONS: In patients with dilated nonischemic cardiomyopathy, scar-related VT, and evidence of low-voltage regions on electroanatomic mapping, endoepicardial homogenization of the scar significantly increased freedom from any recurrent ventricular arrhythmia compared with a standard limited-substrate ablation. However, the success rate with this approach appeared to be lower than previously reported with ischemic cardiomyopathy, presumably because of the septal and midmyocardial distribution of the scar in some patients.

Original languageEnglish
Pages (from-to)1990-1998
Number of pages9
JournalJournal of the American College of Cardiology
Volume68
Issue number18
DOIs
Publication statusPublished - Nov 1 2016

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Cardiomyopathies
Tachycardia
Cicatrix
Ventricular Tachycardia
Cardiac Arrhythmias
Dilated Cardiomyopathy
Stroke Volume
Infarction
Multivariate Analysis

Keywords

  • Journal Article

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Scar Homogenization Versus Limited-Substrate Ablation in Patients With Nonischemic Cardiomyopathy and Ventricular Tachycardia. / Gökoğlan, Yalçın; Mohanty, Sanghamitra; Gianni, Carola; Santangeli, Pasquale; Trivedi, Chintan; Güneş, Mahmut F; Bai, Rong; Al-Ahmad, Amin; Gallinghouse, Joseph G.; Horton, Rodney; Hranitzky, Patrick M; Sanchez, Javier E; Beheiry, Salwa; Hongo, Richard; Lakkireddy, Dhanunjaya; Reddy, Madhu; Schweikert, Robert A.; Dello Russo, Antonio; Casella, Michela; Tondo, Claudio; Burkhardt, J. David; Themistoclakis, Sakis; Di Biase, Luigi; Natale, Andrea.

In: Journal of the American College of Cardiology, Vol. 68, No. 18, 01.11.2016, p. 1990-1998.

Research output: Contribution to journalArticle

Gökoğlan, Y, Mohanty, S, Gianni, C, Santangeli, P, Trivedi, C, Güneş, MF, Bai, R, Al-Ahmad, A, Gallinghouse, JG, Horton, R, Hranitzky, PM, Sanchez, JE, Beheiry, S, Hongo, R, Lakkireddy, D, Reddy, M, Schweikert, RA, Dello Russo, A, Casella, M, Tondo, C, Burkhardt, JD, Themistoclakis, S, Di Biase, L & Natale, A 2016, 'Scar Homogenization Versus Limited-Substrate Ablation in Patients With Nonischemic Cardiomyopathy and Ventricular Tachycardia', Journal of the American College of Cardiology, vol. 68, no. 18, pp. 1990-1998. https://doi.org/10.1016/j.jacc.2016.08.033
Gökoğlan, Yalçın ; Mohanty, Sanghamitra ; Gianni, Carola ; Santangeli, Pasquale ; Trivedi, Chintan ; Güneş, Mahmut F ; Bai, Rong ; Al-Ahmad, Amin ; Gallinghouse, Joseph G. ; Horton, Rodney ; Hranitzky, Patrick M ; Sanchez, Javier E ; Beheiry, Salwa ; Hongo, Richard ; Lakkireddy, Dhanunjaya ; Reddy, Madhu ; Schweikert, Robert A. ; Dello Russo, Antonio ; Casella, Michela ; Tondo, Claudio ; Burkhardt, J. David ; Themistoclakis, Sakis ; Di Biase, Luigi ; Natale, Andrea. / Scar Homogenization Versus Limited-Substrate Ablation in Patients With Nonischemic Cardiomyopathy and Ventricular Tachycardia. In: Journal of the American College of Cardiology. 2016 ; Vol. 68, No. 18. pp. 1990-1998.
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abstract = "BACKGROUND: Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standard limited-substrate ablation in patients with post-infarction ventricular tachycardia (VT). Whether such benefit extends to patients with nonischemic cardiomyopathy and scar-related VT is unclear.OBJECTIVES: The aim of this study was to assess the long-term efficacy of an endoepicardial scar homogenization approach compared with standard ablation in this population.METHODS: Consecutive patients with dilated nonischemic cardiomyopathy (n = 93), scar-related VTs, and evidence of low-voltage regions on the basis of pre-defined criteria on electroanatomic mapping (i.e., bipolar voltage <1.5 mV) underwent either standard VT ablation (group 1 [n = 57]) or endoepicardial ablation of all abnormal potentials within the electroanatomic scar (group 2 [n = 36]). Acute procedural success was defined as noninducibility of any VT at the end of the procedure; long-term success was defined as freedom from any ventricular arrhythmia at follow-up.RESULTS: Acute procedural success rates were 69.4{\%} and 42.1{\%} after scar homogenization and standard ablation, respectively (p = 0.01). During a mean follow-up period of 14 ± 2 months, single-procedure success rates were 63.9{\%} after scar homogenization and 38.6{\%} after standard ablation (p = 0.031). After multivariate analysis, scar homogenization and left ventricular ejection fraction were predictors of long-term success. During follow-up, the rehospitalization rate was significantly lower in the scar homogenization group (p = 0.035).CONCLUSIONS: In patients with dilated nonischemic cardiomyopathy, scar-related VT, and evidence of low-voltage regions on electroanatomic mapping, endoepicardial homogenization of the scar significantly increased freedom from any recurrent ventricular arrhythmia compared with a standard limited-substrate ablation. However, the success rate with this approach appeared to be lower than previously reported with ischemic cardiomyopathy, presumably because of the septal and midmyocardial distribution of the scar in some patients.",
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TY - JOUR

T1 - Scar Homogenization Versus Limited-Substrate Ablation in Patients With Nonischemic Cardiomyopathy and Ventricular Tachycardia

AU - Gökoğlan, Yalçın

AU - Mohanty, Sanghamitra

AU - Gianni, Carola

AU - Santangeli, Pasquale

AU - Trivedi, Chintan

AU - Güneş, Mahmut F

AU - Bai, Rong

AU - Al-Ahmad, Amin

AU - Gallinghouse, Joseph G.

AU - Horton, Rodney

AU - Hranitzky, Patrick M

AU - Sanchez, Javier E

AU - Beheiry, Salwa

AU - Hongo, Richard

AU - Lakkireddy, Dhanunjaya

AU - Reddy, Madhu

AU - Schweikert, Robert A.

AU - Dello Russo, Antonio

AU - Casella, Michela

AU - Tondo, Claudio

AU - Burkhardt, J. David

AU - Themistoclakis, Sakis

AU - Di Biase, Luigi

AU - Natale, Andrea

N1 - Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - BACKGROUND: Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standard limited-substrate ablation in patients with post-infarction ventricular tachycardia (VT). Whether such benefit extends to patients with nonischemic cardiomyopathy and scar-related VT is unclear.OBJECTIVES: The aim of this study was to assess the long-term efficacy of an endoepicardial scar homogenization approach compared with standard ablation in this population.METHODS: Consecutive patients with dilated nonischemic cardiomyopathy (n = 93), scar-related VTs, and evidence of low-voltage regions on the basis of pre-defined criteria on electroanatomic mapping (i.e., bipolar voltage <1.5 mV) underwent either standard VT ablation (group 1 [n = 57]) or endoepicardial ablation of all abnormal potentials within the electroanatomic scar (group 2 [n = 36]). Acute procedural success was defined as noninducibility of any VT at the end of the procedure; long-term success was defined as freedom from any ventricular arrhythmia at follow-up.RESULTS: Acute procedural success rates were 69.4% and 42.1% after scar homogenization and standard ablation, respectively (p = 0.01). During a mean follow-up period of 14 ± 2 months, single-procedure success rates were 63.9% after scar homogenization and 38.6% after standard ablation (p = 0.031). After multivariate analysis, scar homogenization and left ventricular ejection fraction were predictors of long-term success. During follow-up, the rehospitalization rate was significantly lower in the scar homogenization group (p = 0.035).CONCLUSIONS: In patients with dilated nonischemic cardiomyopathy, scar-related VT, and evidence of low-voltage regions on electroanatomic mapping, endoepicardial homogenization of the scar significantly increased freedom from any recurrent ventricular arrhythmia compared with a standard limited-substrate ablation. However, the success rate with this approach appeared to be lower than previously reported with ischemic cardiomyopathy, presumably because of the septal and midmyocardial distribution of the scar in some patients.

AB - BACKGROUND: Scar homogenization improves long-term ventricular arrhythmia-free survival compared with standard limited-substrate ablation in patients with post-infarction ventricular tachycardia (VT). Whether such benefit extends to patients with nonischemic cardiomyopathy and scar-related VT is unclear.OBJECTIVES: The aim of this study was to assess the long-term efficacy of an endoepicardial scar homogenization approach compared with standard ablation in this population.METHODS: Consecutive patients with dilated nonischemic cardiomyopathy (n = 93), scar-related VTs, and evidence of low-voltage regions on the basis of pre-defined criteria on electroanatomic mapping (i.e., bipolar voltage <1.5 mV) underwent either standard VT ablation (group 1 [n = 57]) or endoepicardial ablation of all abnormal potentials within the electroanatomic scar (group 2 [n = 36]). Acute procedural success was defined as noninducibility of any VT at the end of the procedure; long-term success was defined as freedom from any ventricular arrhythmia at follow-up.RESULTS: Acute procedural success rates were 69.4% and 42.1% after scar homogenization and standard ablation, respectively (p = 0.01). During a mean follow-up period of 14 ± 2 months, single-procedure success rates were 63.9% after scar homogenization and 38.6% after standard ablation (p = 0.031). After multivariate analysis, scar homogenization and left ventricular ejection fraction were predictors of long-term success. During follow-up, the rehospitalization rate was significantly lower in the scar homogenization group (p = 0.035).CONCLUSIONS: In patients with dilated nonischemic cardiomyopathy, scar-related VT, and evidence of low-voltage regions on electroanatomic mapping, endoepicardial homogenization of the scar significantly increased freedom from any recurrent ventricular arrhythmia compared with a standard limited-substrate ablation. However, the success rate with this approach appeared to be lower than previously reported with ischemic cardiomyopathy, presumably because of the septal and midmyocardial distribution of the scar in some patients.

KW - Journal Article

U2 - 10.1016/j.jacc.2016.08.033

DO - 10.1016/j.jacc.2016.08.033

M3 - Article

C2 - 27788854

VL - 68

SP - 1990

EP - 1998

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 18

ER -