Scatter-factor and semaphorin receptors: Cell signalling for invasive growth

Livio Trusolino, Paolo M. Comoglio

Research output: Contribution to journalArticle

Abstract

Malignant disease occurs when neoplastic cells abandon their primary site of accretion, cross tissue boundaries and penetrate the vasculature to colonize distant sites. This process - metastasis - is the aberrant counterpart of a physiological programme for organ regeneration and maintenance. Scatter factors and semaphorins, together with their receptors, help to orchestrate this programme. What are the differences between physiological and pathological activation of these signalling molecules, and can we exploit them therapeutically to prevent metastasis?

Original languageEnglish
Pages (from-to)289-300
Number of pages12
JournalNature Reviews Cancer
Volume2
Issue number4
Publication statusPublished - Apr 2002

ASJC Scopus subject areas

  • Cancer Research

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