Abstract
Branching morphogenesis is a multi-step process that controls the formation of polarised tubules starting from hollow cysts. Its execution entails a series of rate-limiting events which include reversible disruption of cell polarity, dismantling of intercellular contacts, acquisition of a motile phenotype, stimulation of cell proliferation, and final re-establishment of cell polarity for creation of the definitive structures. Branching morphogenesis takes place physiologically during development, accounting for the establishment of organs endowed with a ramified architecture such as glands, the respiratory tract and the vascular tree. In cancer, aberrant implementation of branching morphogenesis leads to deregulated proliferation, protection from apoptosis and enhanced migratory/invasive properties, which together exacerbate the aggressive features of neoplastic cells. Under both physiological and pathological conditions, branching morphogenesis is mainly accomplished by a family of growth factors known as scatter factors. In this review, we will summarise the current knowledge on the biological and functional roles of scatter factors during branching morphogenesis, with a special emphasis on the phenotypic (structural and histological) consequences of scatter factor activity in different tissues.
| Original language | English |
|---|---|
| Pages (from-to) | 79-92 |
| Number of pages | 14 |
| Journal | European journal of histochemistry : EJH |
| Volume | 51 |
| Issue number | SUPPL.1 |
| DOIs | |
| Publication status | Published - 2007 |
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Keywords
- Branching morphogenesis
- Cell adhesion and motility
- Scatter factors
- Tyrosine kinases
ASJC Scopus subject areas
- Cell Biology
- Histology
- Biophysics
- Anatomy
- Animal Science and Zoology
- Developmental Biology
Cite this
Scatter factor-dependent branching morphogenesis : Structural and histological features. / Comoglio, Paolo M.; Trusolino, L.; Boccaccio, C.
In: European journal of histochemistry : EJH, Vol. 51, No. SUPPL.1, 2007, p. 79-92.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Scatter factor-dependent branching morphogenesis
T2 - Structural and histological features
AU - Comoglio, Paolo M.
AU - Trusolino, L.
AU - Boccaccio, C.
PY - 2007
Y1 - 2007
N2 - Branching morphogenesis is a multi-step process that controls the formation of polarised tubules starting from hollow cysts. Its execution entails a series of rate-limiting events which include reversible disruption of cell polarity, dismantling of intercellular contacts, acquisition of a motile phenotype, stimulation of cell proliferation, and final re-establishment of cell polarity for creation of the definitive structures. Branching morphogenesis takes place physiologically during development, accounting for the establishment of organs endowed with a ramified architecture such as glands, the respiratory tract and the vascular tree. In cancer, aberrant implementation of branching morphogenesis leads to deregulated proliferation, protection from apoptosis and enhanced migratory/invasive properties, which together exacerbate the aggressive features of neoplastic cells. Under both physiological and pathological conditions, branching morphogenesis is mainly accomplished by a family of growth factors known as scatter factors. In this review, we will summarise the current knowledge on the biological and functional roles of scatter factors during branching morphogenesis, with a special emphasis on the phenotypic (structural and histological) consequences of scatter factor activity in different tissues.
AB - Branching morphogenesis is a multi-step process that controls the formation of polarised tubules starting from hollow cysts. Its execution entails a series of rate-limiting events which include reversible disruption of cell polarity, dismantling of intercellular contacts, acquisition of a motile phenotype, stimulation of cell proliferation, and final re-establishment of cell polarity for creation of the definitive structures. Branching morphogenesis takes place physiologically during development, accounting for the establishment of organs endowed with a ramified architecture such as glands, the respiratory tract and the vascular tree. In cancer, aberrant implementation of branching morphogenesis leads to deregulated proliferation, protection from apoptosis and enhanced migratory/invasive properties, which together exacerbate the aggressive features of neoplastic cells. Under both physiological and pathological conditions, branching morphogenesis is mainly accomplished by a family of growth factors known as scatter factors. In this review, we will summarise the current knowledge on the biological and functional roles of scatter factors during branching morphogenesis, with a special emphasis on the phenotypic (structural and histological) consequences of scatter factor activity in different tissues.
KW - Branching morphogenesis
KW - Cell adhesion and motility
KW - Scatter factors
KW - Tyrosine kinases
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UR - http://www.scopus.com/inward/citedby.url?scp=35148837298&partnerID=8YFLogxK
U2 - 10.4081/1403
DO - 10.4081/1403
M3 - Article
C2 - 17703598
AN - SCOPUS:35148837298
VL - 51
SP - 79
EP - 92
JO - European Journal of Histochemistry
JF - European Journal of Histochemistry
SN - 1121-760X
IS - SUPPL.1
ER -