Scatter Factors in renal disease: Dr. Jeckyll and Mr. Hyde?

Teresa Rampino, Marilena Gregorini, Antonio Dal Canton

Research output: Contribution to journalArticlepeer-review

Abstract

The Scatter Factors are two homologous proteins, named Scatter Factor/Hepatocyte Growth Factor and Macrophage Stimulating Protein. Their receptors are the products of two oncogenes, Met and Ron, respectively. The Scatter Factors induce movement, stimulate proliferation, regulate apoptosis and are morphogenic, i.e. operate an integrated program that seems tailored to drive organ development and to regenerate injured tissues. On the other hand, Scatter Factors may be responsible for pathologic tissue remodeling, infiltration of inflammatory cells, and tumor growth and diffusion. The review describes the involvement of Scatter Factors in renal disease, including acute renal failure, glomerulonephritis, chronic fibrosing nephropathies, dialysis, renal transplantation and renal tumors, and discusses the double-faced role of Scatter Factors, that play either a protective or a pathogenic role.

Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume20
Issue number1
DOIs
Publication statusPublished - Feb 2009

Keywords

  • Acute renal failure
  • Glomerulonephritis
  • Hepatocyte Growth Factor
  • Scatter Factors

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

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