Scavenger receptors and non-coding RNAs: Relevance in atherogenesis

Yao Dai, Gianluigi Condorelli, Jawahar L. Mehta

Research output: Contribution to journalArticle

Abstract

Scavenger receptors (SRs), which recognize modified low-density lipoprotein (LDL) by oxidation or acetylation, are a group of receptors on plasma membrane of macrophages and other cell types. These receptors by facilitating modified LDL uptake are a primary step in the intracellular accumulation of modified LDL and formation of fatty streak. Non-coding RNAs (ncRNAs) are a group of functional RNA nucleotides that are not translated into protein, and include microRNAs (miRs), snoRNAs, siRNAs, snRNAs, exRNAs, piRNAs, and the long ncRNAs (lncRNAs). Recently, ncRNAs have received much attention due to their effects in a variety of disease states such as atherosclerotic cardiovascular disease and cancers. A host of ncRNAs, such as miRs and lncRNAs, have been found to be involved in the regulation of SRs and the inflammatory cascade and subsequently atherosclerosis. Here, we review this important area to create interest in this growing field among researchers and clinicians alike.

Original languageEnglish
Pages (from-to)24-33
Number of pages10
JournalCardiovascular Research
Volume109
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Atherogenesis
  • Non-coding RNA
  • Scavenger receptor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

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