Scenery of Staphylococcus implant infections in orthopedics

Lucio Montanaro, Pietro Speziale, Davide Campoccia, Stefano Ravaioli, Ilaria Cangini, Giampiero Pietrocola, Sandro Giannini, Carla Renata Arciola

Research output: Contribution to journalArticlepeer-review


Infection is still the major complication of orthopedic implants and projections based on the actual trend indicate that total hip and knee arthroplasties and their consequent infection burden are destined to greatly increase. Staphylococcus aureus and Staphylococcus epidermidis are the leading etiologic agents of orthopedic implant infection. Here we report on epidemiology of implant-related Staphylococcus infections in orthopedics, also referring to our experience, and focus on the crucial role of bacterial adhesins and on their ability to direct the pathogenesis process. Bacteria initiate implant infection by adhering to biomaterials. In the early steps of infection, adhesins mediate the specific interaction between microbial cells and the extracellular matrix proteins filming biomaterial surface. Then adhesin-mediated anchorage allows bacteria to cling to the biomaterial surface and to produce a biofilm that favors their ability to resist antibiotics. With the aim to prevent implant-related infections, anti-infective and infection-resistant biomaterials are being developed. The research for novel therapeutic strategies is incited by the emergence of antibiotic-resistant bacteria. Vaccines against the adhesins or antisense molecules against virulence genes can open a future in combating implant infections.

Original languageEnglish
Pages (from-to)1329-1349
Number of pages21
JournalFuture Microbiology
Issue number11
Publication statusPublished - Nov 2011


  • Adhesins
  • Antibiotic-loaded biomaterials
  • Biofilm
  • DNA vaccines
  • Implant infections
  • Infection-resistant materials
  • Orthopedic implants
  • Peptide-nucleicacids
  • Staphylococcus aureus
  • Staphylococcus epidermidis
  • Vaccines

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


Dive into the research topics of 'Scenery of Staphylococcus implant infections in orthopedics'. Together they form a unique fingerprint.

Cite this