Schedule-dependent effectiveness of ADM and multiple cycles of DDP on a murine reticulum sarcoma

C. Leonetti, G. Zupi, F. Calabresi, C. Greco

Research output: Contribution to journalArticlepeer-review


The therapeutic index of adriamycin (ADM) and cisplatin (DDP) combination versus repeated sequences of the more active drug (DDP) was investigated on a murine reticulum cell sarcoma of ovarian origin (M5) implanted i.m. in C57BL/6 mice. The antitumor efficacy of multiple cycles of DDP according to different regimens at a prefixed time (every 7 days) or at tumor regrowth was also evaluated. Our data demonstrate that the ADM-DDP combination did not improve the antitumoral efficacy of DDP as single agent, while repeated cycles of DDP led to a significant increase in the host life span. Differences in therapeutic effect were elicited by the two schedules: the regimen at a prefixed time showed a major effect on local tumor control, although the regimen at tumor regrowth was better tolerated.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalAnticancer Research
Issue number1
Publication statusPublished - 1990


  • adriamycin
  • cisplatin
  • combination vs single agent chemotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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