Abstract
The therapeutic index of adriamycin (ADM) and cisplatin (DDP) combination versus repeated sequences of the more active drug (DDP) was investigated on a murine reticulum cell sarcoma of ovarian origin (M5) implanted i.m. in C57BL/6 mice. The antitumor efficacy of multiple cycles of DDP according to different regimens at a prefixed time (every 7 days) or at tumor regrowth was also evaluated. Our data demonstrate that the ADM-DDP combination did not improve the antitumoral efficacy of DDP as single agent, while repeated cycles of DDP led to a significant increase in the host life span. Differences in therapeutic effect were elicited by the two schedules: the regimen at a prefixed time showed a major effect on local tumor control, although the regimen at tumor regrowth was better tolerated.
Original language | English |
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Pages (from-to) | 45-48 |
Number of pages | 4 |
Journal | Anticancer Research |
Volume | 10 |
Issue number | 1 |
Publication status | Published - 1990 |
Keywords
- adriamycin
- cisplatin
- combination vs single agent chemotherapy
ASJC Scopus subject areas
- Cancer Research
- Oncology