Schizophrenia severity, social functioning and hippocampal neuroanatomy: Three-dimensional mapping study

Paolo Brambilla, C. Perlini, P. Rajagopalan, P. Saharan, G. Rambaldelli, M. Bellani, N. Dusi, R. Cerini, R. Pozzi Mucelli, M. Tansella, P. M. Thompson

Research output: Contribution to journalArticle

Abstract

Background: Hippocampal shrinkage is commonly reported in schizophrenia, but its role in the illness is still poorly understood. In particular, it is unclear how clinical and psychosocial variables relate to hippocampal volumes. Aims: To investigate neuroanatomic differences in the hippocampus using three-dimensional (3D) computational image analysis. Method: We used high-resolution magnetic resonance imaging and surface-based modelling to map the 3D profile of hippocampal differences in adults with schizophrenia (n = 67) and a healthy control group (n = 72). Manual tracings were used to create 3D parametric mesh models of the hippocampus. Regression models were used to relate diagnostic measures to maps of radial distance, and colourcoded maps were generated to show the profile of associations. Results: There was no detectable difference between the schizophrenia and control groups in hippocampal radial distance. In the schizophrenia group, however, bilateral shape deflation was associated with greater illness severity (length of illness, positive and negative symptoms) and with poorer social functioning (educational level, quality of life and health status), which survived Bonferroni correction. Conclusions: Illness severity and poor social functioning may be associated with hippocampal deflation in schizophrenia. As a structural sign of poor outcome, imaging measures might help to identify a subgroup of patients who may need specific treatment to resist hippocampal shrinkage, such as cognitive rehabilitation or physical exercise.

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalBritish Journal of Psychiatry
Volume202
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Neuroanatomy
Schizophrenia
Hippocampus
Exercise Therapy
Control Groups
Health Status
Quality of Life
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Exercise

ASJC Scopus subject areas

  • Psychiatry and Mental health

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Schizophrenia severity, social functioning and hippocampal neuroanatomy : Three-dimensional mapping study. / Brambilla, Paolo; Perlini, C.; Rajagopalan, P.; Saharan, P.; Rambaldelli, G.; Bellani, M.; Dusi, N.; Cerini, R.; Pozzi Mucelli, R.; Tansella, M.; Thompson, P. M.

In: British Journal of Psychiatry, Vol. 202, No. 1, 01.2013, p. 50-55.

Research output: Contribution to journalArticle

Brambilla, P, Perlini, C, Rajagopalan, P, Saharan, P, Rambaldelli, G, Bellani, M, Dusi, N, Cerini, R, Pozzi Mucelli, R, Tansella, M & Thompson, PM 2013, 'Schizophrenia severity, social functioning and hippocampal neuroanatomy: Three-dimensional mapping study', British Journal of Psychiatry, vol. 202, no. 1, pp. 50-55. https://doi.org/10.1192/bjp.bp.111.105700
Brambilla, Paolo ; Perlini, C. ; Rajagopalan, P. ; Saharan, P. ; Rambaldelli, G. ; Bellani, M. ; Dusi, N. ; Cerini, R. ; Pozzi Mucelli, R. ; Tansella, M. ; Thompson, P. M. / Schizophrenia severity, social functioning and hippocampal neuroanatomy : Three-dimensional mapping study. In: British Journal of Psychiatry. 2013 ; Vol. 202, No. 1. pp. 50-55.
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