Schizophrenic patients before and after HIV infection: A case-control study

M. C. Mauri, L. Fabiano, S. Bravin, C. Ricci, G. Invernizzi

Research output: Contribution to journalArticlepeer-review

Abstract

Thirteen HIV positive schizophrenic patients (Group 1), age ranging from 23 to 60 years, diagnosed as schizophrenics (DSM IV), were studied during a four week hospitalization period, due to an acute exacerbation phase. The patients were treated with haloperidol (3-15 mg/die p.o.) and diazepam (2-25 mg/die p.o.). Clinical picture and side-effects were assessed by BPRS, HRS- A, HRS-D, and DOTES, at admission and after 2, 3, 4 weeks of hospitalization period (Time 5, 7, 8, 9). Clinical evaluations were compared to a previous hospitalization period, before seroconversion (Time 0, 2, 3, 4), and to a control group (Group 2) of HIV negative schizophrenic patients (11 pb) followed as well during 2 periods of hospitalization. Our data seem to emphasize that the HIV infection could induce organic alterations in the CNS which might cause psychopathological consequences: significantly more severe depressive symptomatology and a reduction of tolerability to neuroleptics in the seroconverted patients' group.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalEncephale
Volume23
Issue number6
Publication statusPublished - Nov 1997

Keywords

  • Depression
  • HIV infection
  • Neuroleptic tolerability
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

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