TY - JOUR
T1 - Schwann cell hamartoma
T2 - Case report
AU - Rocco, Elena G.
AU - Iannuzzi, Francesca
AU - Dell'Era, Alessandra
AU - Falleni, Monica
AU - Moneghini, Laura
AU - Di Nuovo, Franca
AU - Braidotti, Paola
AU - Bulfamante, Gaetano
AU - Romagnoli, Solange
PY - 2011/6/10
Y1 - 2011/6/10
N2 - Background: Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.Case presentation: We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.Conclusion: As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.
AB - Background: Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.Case presentation: We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.Conclusion: As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.
KW - colonic polyp
KW - Gastrointestinal stromal tumors
KW - Hamartoma
KW - Schwann cell
KW - Schwannoma
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U2 - 10.1186/1471-230X-11-68
DO - 10.1186/1471-230X-11-68
M3 - Article
C2 - 21663626
AN - SCOPUS:79959535564
VL - 11
JO - BMC Gastroenterology
JF - BMC Gastroenterology
SN - 1471-230X
M1 - 68
ER -