Schwann cell hamartoma: Case report

Elena G. Rocco; Francesca Iannuzzi; Alessandra Dell'Era; Monica Falleni; Laura Moneghini; Franca Di Nuovo; Paola Braidotti; Gaetano Bulfamante; Solange Romagnoli

doi:10.1186/1471-230X-11-68

Schwann cell hamartoma: Case report

Elena G. Rocco, Francesca Iannuzzi, Alessandra Dell'Era, Monica Falleni, Laura Moneghini, Franca Di Nuovo, Paola Braidotti, Gaetano Bulfamante, Solange Romagnoli

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.Case presentation: We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.Conclusion: As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.

Original language	English
Article number	68
Journal	BMC Gastroenterology
Volume	11
DOIs	https://doi.org/10.1186/1471-230X-11-68
Publication status	Published - Jun 10 2011

Keywords

colonic polyp
Gastrointestinal stromal tumors
Hamartoma
Schwann cell
Schwannoma

ASJC Scopus subject areas

Gastroenterology

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title = "Schwann cell hamartoma: Case report",

abstract = "Background: Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.Case presentation: We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.Conclusion: As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.",

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T2 - Case report

AU - Rocco, Elena G.

AU - Iannuzzi, Francesca

AU - Dell'Era, Alessandra

AU - Falleni, Monica

AU - Moneghini, Laura

AU - Di Nuovo, Franca

AU - Braidotti, Paola

AU - Bulfamante, Gaetano

AU - Romagnoli, Solange

PY - 2011/6/10

Y1 - 2011/6/10

N2 - Background: Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.Case presentation: We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.Conclusion: As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.

AB - Background: Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.Case presentation: We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.Conclusion: As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.

KW - colonic polyp

KW - Gastrointestinal stromal tumors

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KW - Schwann cell

KW - Schwannoma

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