Schwann cell hamartoma: Case report

Elena G. Rocco; Francesca Iannuzzi; Alessandra Dell'Era; Monica Falleni; Laura Moneghini; Franca Di Nuovo; Paola Braidotti; Gaetano Bulfamante; Solange Romagnoli

doi:10.1186/1471-230X-11-68

Schwann cell hamartoma: Case report

Elena G. Rocco, Francesca Iannuzzi, Alessandra Dell'Era, Monica Falleni, Laura Moneghini, Franca Di Nuovo, Paola Braidotti, Gaetano Bulfamante, Solange Romagnoli

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article

Abstract

Background: Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.Case presentation: We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.Conclusion: As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.

Original language	English
Article number	68
Journal	BMC Gastroenterology
Volume	11
DOIs	https://doi.org/10.1186/1471-230X-11-68
Publication status	Published - Jun 10 2011

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Keywords

colonic polyp
Gastrointestinal stromal tumors
Hamartoma
Schwann cell
Schwannoma

ASJC Scopus subject areas

Gastroenterology

Cite this

Rocco, E. G., Iannuzzi, F., Dell'Era, A., Falleni, M., Moneghini, L., Di Nuovo, F., Braidotti, P., Bulfamante, G., & Romagnoli, S. (2011). Schwann cell hamartoma: Case report. BMC Gastroenterology, 11, [68]. https://doi.org/10.1186/1471-230X-11-68

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AU - Iannuzzi, Francesca

AU - Dell'Era, Alessandra

AU - Falleni, Monica

AU - Moneghini, Laura

AU - Di Nuovo, Franca

AU - Braidotti, Paola

AU - Bulfamante, Gaetano

AU - Romagnoli, Solange

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10.1186/1471-230X-11-68