Schwann cell hamartoma: Case report

Elena G. Rocco, Francesca Iannuzzi, Alessandra Dell'Era, Monica Falleni, Laura Moneghini, Franca Di Nuovo, Paola Braidotti, Gaetano Bulfamante, Solange Romagnoli

Research output: Contribution to journalArticlepeer-review


Background: Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.Case presentation: We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.Conclusion: As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.

Original languageEnglish
Article number68
JournalBMC Gastroenterology
Publication statusPublished - Jun 10 2011


  • colonic polyp
  • Gastrointestinal stromal tumors
  • Hamartoma
  • Schwann cell
  • Schwannoma

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Schwann cell hamartoma: Case report'. Together they form a unique fingerprint.

Cite this