Sciatic nerve block with 0.5% levobupivacaine, 0.75% levobupivacaine or 0.75% ropivacaine: A double-blind, randomized comparison

Andrea Casati, F. Vinciguerra, R. Santorsola, G. Aldegheri, M. Putzu, G. Fanelli

Research output: Contribution to journalArticle

Abstract

Background and objective: This prospective, randomized, double-blind study was conducted to evaluate the onset time and duration of sciatic nerve block produced with 0.5% levobupivacaine, 0.75% levobupivacaine and 0.75% ropivacaine. Methods: Forty-five healthy patients undergoing hallux valgus repair were randomly allocated to receive sciatic nerve block with levobupivacaine 0.5% (n = 15), levobupivacaine 0.75% (n = 15) or ropivacaine 0.75% 20 mL (n = 15). A femoral nerve block was also performed with mepivacaine 2% 15 mL to cover pain related to the thigh tourniquet. A blinded observer recorded the onset time and duration of sciatic nerve block. Results: The median (range) onset time was 5 (5-40) min with 0.75% levobupivacaine, 30 (5-60) min with 0.5% levobupivacaine and 20 (5-50) min with 0.75% ropivacaine (P = 0.02 and P -0.12, respectively). Mean (25-75 percentiles) first request for pain medication occurred after 13 (11-14) h with 0.75% ropivacaine, 18 (15-19) h with 0.75% levobupivacaine and 16 (13-20) h with 0.5% levobupivacaine (P = 0.002 and P = 0.002, respectively). Rescue tramadol after surgery was required by three patients in the 0.75% levobupivacaine group, eight patients in the 0.5% levobupivacaine group and nine patients in the 0.75% ropivacaine group (P = 0.05). Conclusions: We conclude that 0.75% levobupivacaine provides a shorter onset time than 0.5% levobupivacaine and a longer duration of postoperative analgesia than both 0.5% levobupivacaine and 0.75% ropivacaine with reduced need for rescue analgesia after surgery.

Original languageEnglish
Pages (from-to)452-456
Number of pages5
JournalEuropean Journal of Anaesthesiology
Volume22
Issue number6
DOIs
Publication statusPublished - Jun 2005

Fingerprint

Nerve Block
Sciatic Nerve
levobupivacaine
ropivacaine
Analgesia
Mepivacaine
Femoral Nerve
Hallux Valgus
Pain
Tramadol
Tourniquets
Thigh
Double-Blind Method

Keywords

  • Anaesthetic techniques, regional, sciatic nerve block
  • Anaesthetic, local, ropivacaine, levobupivacaine
  • Surgery, orthopaedic, hallux valgus repair

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Sciatic nerve block with 0.5% levobupivacaine, 0.75% levobupivacaine or 0.75% ropivacaine : A double-blind, randomized comparison. / Casati, Andrea; Vinciguerra, F.; Santorsola, R.; Aldegheri, G.; Putzu, M.; Fanelli, G.

In: European Journal of Anaesthesiology, Vol. 22, No. 6, 06.2005, p. 452-456.

Research output: Contribution to journalArticle

Casati, Andrea ; Vinciguerra, F. ; Santorsola, R. ; Aldegheri, G. ; Putzu, M. ; Fanelli, G. / Sciatic nerve block with 0.5% levobupivacaine, 0.75% levobupivacaine or 0.75% ropivacaine : A double-blind, randomized comparison. In: European Journal of Anaesthesiology. 2005 ; Vol. 22, No. 6. pp. 452-456.
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abstract = "Background and objective: This prospective, randomized, double-blind study was conducted to evaluate the onset time and duration of sciatic nerve block produced with 0.5{\%} levobupivacaine, 0.75{\%} levobupivacaine and 0.75{\%} ropivacaine. Methods: Forty-five healthy patients undergoing hallux valgus repair were randomly allocated to receive sciatic nerve block with levobupivacaine 0.5{\%} (n = 15), levobupivacaine 0.75{\%} (n = 15) or ropivacaine 0.75{\%} 20 mL (n = 15). A femoral nerve block was also performed with mepivacaine 2{\%} 15 mL to cover pain related to the thigh tourniquet. A blinded observer recorded the onset time and duration of sciatic nerve block. Results: The median (range) onset time was 5 (5-40) min with 0.75{\%} levobupivacaine, 30 (5-60) min with 0.5{\%} levobupivacaine and 20 (5-50) min with 0.75{\%} ropivacaine (P = 0.02 and P -0.12, respectively). Mean (25-75 percentiles) first request for pain medication occurred after 13 (11-14) h with 0.75{\%} ropivacaine, 18 (15-19) h with 0.75{\%} levobupivacaine and 16 (13-20) h with 0.5{\%} levobupivacaine (P = 0.002 and P = 0.002, respectively). Rescue tramadol after surgery was required by three patients in the 0.75{\%} levobupivacaine group, eight patients in the 0.5{\%} levobupivacaine group and nine patients in the 0.75{\%} ropivacaine group (P = 0.05). Conclusions: We conclude that 0.75{\%} levobupivacaine provides a shorter onset time than 0.5{\%} levobupivacaine and a longer duration of postoperative analgesia than both 0.5{\%} levobupivacaine and 0.75{\%} ropivacaine with reduced need for rescue analgesia after surgery.",
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T2 - A double-blind, randomized comparison

AU - Casati, Andrea

AU - Vinciguerra, F.

AU - Santorsola, R.

AU - Aldegheri, G.

AU - Putzu, M.

AU - Fanelli, G.

PY - 2005/6

Y1 - 2005/6

N2 - Background and objective: This prospective, randomized, double-blind study was conducted to evaluate the onset time and duration of sciatic nerve block produced with 0.5% levobupivacaine, 0.75% levobupivacaine and 0.75% ropivacaine. Methods: Forty-five healthy patients undergoing hallux valgus repair were randomly allocated to receive sciatic nerve block with levobupivacaine 0.5% (n = 15), levobupivacaine 0.75% (n = 15) or ropivacaine 0.75% 20 mL (n = 15). A femoral nerve block was also performed with mepivacaine 2% 15 mL to cover pain related to the thigh tourniquet. A blinded observer recorded the onset time and duration of sciatic nerve block. Results: The median (range) onset time was 5 (5-40) min with 0.75% levobupivacaine, 30 (5-60) min with 0.5% levobupivacaine and 20 (5-50) min with 0.75% ropivacaine (P = 0.02 and P -0.12, respectively). Mean (25-75 percentiles) first request for pain medication occurred after 13 (11-14) h with 0.75% ropivacaine, 18 (15-19) h with 0.75% levobupivacaine and 16 (13-20) h with 0.5% levobupivacaine (P = 0.002 and P = 0.002, respectively). Rescue tramadol after surgery was required by three patients in the 0.75% levobupivacaine group, eight patients in the 0.5% levobupivacaine group and nine patients in the 0.75% ropivacaine group (P = 0.05). Conclusions: We conclude that 0.75% levobupivacaine provides a shorter onset time than 0.5% levobupivacaine and a longer duration of postoperative analgesia than both 0.5% levobupivacaine and 0.75% ropivacaine with reduced need for rescue analgesia after surgery.

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KW - Surgery, orthopaedic, hallux valgus repair

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