Science signaling podcast: 30 april 2013

Elena M. Borroni, Raffaella Bonecchi, Annalisa M. Vanhook

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This Podcast features an interview with Elena M. Borroni and Raffaella Bonecchi, authors of a Research Article that appears in the 30 April 2013 issue of Science Signaling. Chemokines recruit leukocytes to sites of infection and inflammation by binding to chemokine receptors, which are members of the G protein-coupled receptor superfamily, present on the surface of leukocytes. Whereas activation of typical chemokine receptors leads to G protein-dependent signaling that promotes cell migration toward the chemokine source, activation of atypical chemokine receptors does not promote cell migration. Instead, signaling initiated by atypical chemokine receptors contributes to the immune response in other ways. The atypical chemokine receptor D6 is a scavenger that alters the chemokine gradient by binding to and degrading chemokines. Borroni and Bonecchi found that activation of a β-arrestin-dependent signaling pathway was necessary for D6 to act as a chemokine scavenger.

Original languageEnglish
JournalScience Signaling
Volume6
Issue number273
DOIs
Publication statusPublished - Apr 30 2013

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Webcasts
Chemokines
Chemokine Receptors
Chemical activation
Cell Movement
Leukocytes
Arrestin
G-Protein-Coupled Receptors
GTP-Binding Proteins
Interviews
Inflammation
Infection
Research

Keywords

  • β-Arrestin
  • Atypical Chemokine Receptor D6
  • Beta-Arrestin
  • Biased Signaling
  • Cell Migration
  • Chemokine Gradient
  • Chemokine Scavenger
  • Chemotaxis
  • G Protein-Coupled Receptor
  • Gpcr
  • Immune Response
  • Inflammation
  • Leukocyte
  • Science Signaling

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Science signaling podcast : 30 april 2013. / Borroni, Elena M.; Bonecchi, Raffaella; Vanhook, Annalisa M.

In: Science Signaling, Vol. 6, No. 273, 30.04.2013.

Research output: Contribution to journalArticle

Borroni, Elena M. ; Bonecchi, Raffaella ; Vanhook, Annalisa M. / Science signaling podcast : 30 april 2013. In: Science Signaling. 2013 ; Vol. 6, No. 273.
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