Scientific foundation and possible implications for practice of the minimizing adverse haemorrhagic events by transradial access site and systemic implementation of AngioX (MATRIX) trial

Marco Valgimigli, Paolo Calabrò, Bernardo Cortese, Enrico Frigoli, Stefano Garducci, Paolo Rubartelli, Giuseppe Andò, Andrea Santarelli, Mario Galli, Roberto Garbo, Alessandra Repetto, Salvatore Ierna, Carlo Briguori, Ugo Limbruno, Roberto Violini, Andrea Gagnor

Research output: Contribution to journalArticlepeer-review

Abstract

Early invasive management and the use of combined antithrombotic therapies have decreased the risk of recurrent ischaemia in patients with acute coronary syndrome (ACS) but have also increased the bleeding risk. Transradial intervention (TRI) and bivalirudin infusion compared to transfemoral intervention (TFI) or unfractionated heparin (UFH) plus glycoprotein IIb/IIIa inhibitors (GPI) decrease bleeding complications in patients with ACS. To what extent, a bleeding preventive strategy incorporating at least one of these two treatment options translates into improved outcomes is a matter of debate. The Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX study is a large-scale, multicenter, prospective, open-label trial, conducted at approximately 100 sites in Europe aiming to primarily assess whether TRI and bivalirudin infusion, as compared to TFI and UFH plus provisional GPI, decrease the 30-day incidence of death, myocardial infarction or stroke across the whole spectrum of ACS patients.

Original languageEnglish
Pages (from-to)101-111
Number of pages11
JournalJournal of Cardiovascular Translational Research
Volume7
Issue number1
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Acute coronary syndromes
  • Anti-thrombin
  • Bivalirudin
  • Bleeding complications
  • MATRIX
  • Transradial intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science

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