Scintigraphic, neuroradiological and clinical comparison in two patients with primary sporadic and two with secondary Fahr's disease

Giovanni Caranci, Giovanni Grillea, Francesco Barbato, Alexandra Brunetti, Tiziana Tassinari, Mariarita Di Ruzza, Francesco Lena, Barbara Gandolfi, Anna Elisa Castellano, Marcello Bartolo, Claudio Colonnese, Nicola Modugno, Stefano Ruggieri, Mario Manfredi

Research output: Contribution to journalArticlepeer-review

Abstract

Bilateral striopallidodentate calcification, usually termed Fahr's disease, can give rise to various clinical manifestations including hyperkinetic movement disorders or a hypokinetic Parkinsonian syndrome, behavioural and mood changes, cognitive deficits and even frank dementia. We describe four patients all of whom underwent a detailed scintigraphic, neuroradiological and clinical work-up: two had primary, sporadic Fahr's disease and two had Fahr's disease secondary to hypoparathyroidism. The neuroradiological and clinical studies disclosed similar anatomical and pathological changes in the four patients but variable and sometimes unexpected clinical manifestations. Both patients with primary forms had hypokinetic Parkinsonian syndrome, both patients with secondary forms had hyperkinetic movements. Dopamine autotransporter scan brain scintigraphy disclosed an unexpected unilateral putamen involvement despite substantially symmetric calcifications.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalNeurological Sciences
Volume32
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Fahr's disease
  • Functional imaging
  • Hyperkinetic movements
  • Hypoparathyroidism

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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