Scintimammography with technetium-99m tetrofosmin in suspected breast cancer

Orazio Schillaci, Francesco Scopinaro, Roberta Danieli, Valentina Picardi, Rosanna Tavolaro, Pina Cannas, Antonio Centi Colella

Research output: Contribution to journalArticlepeer-review


Background. Scintimammography with Tc-99m sestamibi has recently demonstrated a clinical usefulness in the evaluation of patients with breast lesions. The aim of this study was to assess the potential role of scintimammography using Tc-99m tetrofosmin in the detection of breast cancer. Materials and Methods. Fifty-five patients (age range: 33-76 years) with suspicious breast abnormalities detected by mammography, and ten controls were examined. Dynamic images (1-20 min post-injection of the radiopharmaceutical) followed by three planar views were performed. Final diagnosis was achieved by hystology after surgery or excisional biopsy. Results. A total of 59 breast lesions were considered. The sensitivity of Tc-99m tetrofosmin scintimammography for detection of primary breast cancer was 93.1% (27/29) and the specificity was 93.3% (28/30). No focal uptake was observed in both breasts of the control population. Conclusions. Tc-99m tetrofosmin scintimammography has high diagnostic accuracy in detecting breast cancer and may have a clinical role as complement to conventional mammography.

Original languageEnglish
Pages (from-to)1623-1626
Number of pages4
JournalAnticancer Research
Issue number3 B
Publication statusPublished - 1997


  • Breast cancer
  • Scintimammography
  • Technetium-99m tetrofosmin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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