Abstract
Scleromyxedema is the generalized and sclerodermoid form of lichen myxedematosus. Its typical histological features include a diffuse deposition of mucin in the papillary and mid reticular dermis, an increased of collagen deposition, and a proliferation of irregularly arranged fibroblasts. We describe a 76-year-old man presenting with scleromyxedema associated with IgGλ monoclonal gammopathy whose biopsy showed histological features of an interstitial granulomatous-like process consistent with interstitial granuloma annulare. The significance of these unusual granulomatous findings in the setting of scleromyxedema are unknown and have been described only once in the literature. This observation expands the spectrum of scleromyxedema and highlights the difficulty in diagnosing this disabling condition. Rongioletti F, Cozzani E, Parodi A. Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare.
| Original language | English |
|---|---|
| Pages (from-to) | 1084-1087 |
| Number of pages | 4 |
| Journal | Journal of Cutaneous Pathology |
| Volume | 37 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2010 |
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ASJC Scopus subject areas
- Dermatology
- Pathology and Forensic Medicine
- Histology
Cite this
Scleromyxedema with an interstitial granulomatous-like pattern : A rare histologic variant mimicking granuloma annulare. / Rongioletti, Franco; Cozzani, Emanuele; Parodi, Aurora.
In: Journal of Cutaneous Pathology, Vol. 37, No. 10, 10.2010, p. 1084-1087.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Scleromyxedema with an interstitial granulomatous-like pattern
T2 - A rare histologic variant mimicking granuloma annulare
AU - Rongioletti, Franco
AU - Cozzani, Emanuele
AU - Parodi, Aurora
PY - 2010/10
Y1 - 2010/10
N2 - Scleromyxedema is the generalized and sclerodermoid form of lichen myxedematosus. Its typical histological features include a diffuse deposition of mucin in the papillary and mid reticular dermis, an increased of collagen deposition, and a proliferation of irregularly arranged fibroblasts. We describe a 76-year-old man presenting with scleromyxedema associated with IgGλ monoclonal gammopathy whose biopsy showed histological features of an interstitial granulomatous-like process consistent with interstitial granuloma annulare. The significance of these unusual granulomatous findings in the setting of scleromyxedema are unknown and have been described only once in the literature. This observation expands the spectrum of scleromyxedema and highlights the difficulty in diagnosing this disabling condition. Rongioletti F, Cozzani E, Parodi A. Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare.
AB - Scleromyxedema is the generalized and sclerodermoid form of lichen myxedematosus. Its typical histological features include a diffuse deposition of mucin in the papillary and mid reticular dermis, an increased of collagen deposition, and a proliferation of irregularly arranged fibroblasts. We describe a 76-year-old man presenting with scleromyxedema associated with IgGλ monoclonal gammopathy whose biopsy showed histological features of an interstitial granulomatous-like process consistent with interstitial granuloma annulare. The significance of these unusual granulomatous findings in the setting of scleromyxedema are unknown and have been described only once in the literature. This observation expands the spectrum of scleromyxedema and highlights the difficulty in diagnosing this disabling condition. Rongioletti F, Cozzani E, Parodi A. Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare.
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U2 - 10.1111/j.1600-0560.2009.01386.x
DO - 10.1111/j.1600-0560.2009.01386.x
M3 - Article
C2 - 19638067
AN - SCOPUS:77955669137
VL - 37
SP - 1084
EP - 1087
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
SN - 0303-6987
IS - 10
ER -