Scleromyxedema with an interstitial granulomatous-like pattern: A rare histologic variant mimicking granuloma annulare

Franco Rongioletti, Emanuele Cozzani, Aurora Parodi

Research output: Contribution to journalArticle

Abstract

Scleromyxedema is the generalized and sclerodermoid form of lichen myxedematosus. Its typical histological features include a diffuse deposition of mucin in the papillary and mid reticular dermis, an increased of collagen deposition, and a proliferation of irregularly arranged fibroblasts. We describe a 76-year-old man presenting with scleromyxedema associated with IgGλ monoclonal gammopathy whose biopsy showed histological features of an interstitial granulomatous-like process consistent with interstitial granuloma annulare. The significance of these unusual granulomatous findings in the setting of scleromyxedema are unknown and have been described only once in the literature. This observation expands the spectrum of scleromyxedema and highlights the difficulty in diagnosing this disabling condition. Rongioletti F, Cozzani E, Parodi A. Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare.

Original languageEnglish
Pages (from-to)1084-1087
Number of pages4
JournalJournal of Cutaneous Pathology
Volume37
Issue number10
DOIs
Publication statusPublished - Oct 2010

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Scleromyxedema
Granuloma Annulare
Paraproteinemias
Mucins
Dermis
Collagen
Fibroblasts
Immunoglobulin G
Biopsy

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine
  • Histology

Cite this

Scleromyxedema with an interstitial granulomatous-like pattern : A rare histologic variant mimicking granuloma annulare. / Rongioletti, Franco; Cozzani, Emanuele; Parodi, Aurora.

In: Journal of Cutaneous Pathology, Vol. 37, No. 10, 10.2010, p. 1084-1087.

Research output: Contribution to journalArticle

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