Sclerosing angiomatoid nodular transformation of the spleen during pregnancy: Diagnostic challenges and clinical management

Giacomo Corrado, Valentina Tabanelli, Roberto Biffi, Giuseppe Petralia, Andrea Tinelli, Fedro A. Peccatori

Research output: Contribution to journalArticlepeer-review

Abstract

We report the first case of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed during pregnancy, discussing differential diagnosis, immunohistochemical profile and treatment. A G2P1 37-year-old woman presented during the 19th week of gestation because of pruritus at lower limbs. To exclude cholestasis, an abdominal ultrasound and whole body magnetic resonance were performed and a single solid lesion with intrinsic vascularization was identified. Therefore, at 22 weeks gestation, after normal fetal assessment, the patient was referred for a splenectomy. No further treatment was suggested and the patient gave birth at 42 weeks gestation with a spontaneous delivery. Distinguishing SANT from other vascular neoplasms of the spleen during pregnancy is a difficult task. Surgical excision should be performed to exclude malignancy and to resolve symptoms, if present.

Original languageEnglish
Pages (from-to)1021-1025
Number of pages5
JournalJournal of Obstetrics and Gynaecology Research
Volume42
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • pregnancy
  • sclerosing angiomatoid nodular transformation
  • spleen

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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