TY - JOUR
T1 - Sclerostin and DKK-1
T2 - two important regulators of bone metabolism in HIV-infected youths
AU - Mora, Stefano
AU - Puzzovio, Maria
AU - Giacomet, Vania
AU - Fabiano, Valentina
AU - Maruca, Katia
AU - Capelli, Silvia
AU - Nannini, Pilar
AU - Lombardi, Giovanni
AU - Zuccotti, Gian Vincenzo
PY - 2015/8/27
Y1 - 2015/8/27
N2 - Reduced bone mineral density (BMD) and altered bone metabolism are common findings in HIV-infected patients. Increased bone formation has been described both in HIV-infected adults and children. Wnt ligands promote bone formation by stimulating osteoblast differentiation and their survival. Sclerostin and dickkopf factor 1 (DKK-1), Wnt antagonists, are important negative regulators of bone formation. We studied 86 HIV-infected patients whose ages ranged from 5.7 to 27.9 years. Patients were all on antiretroviral therapy, but seven who were naïve to treatment. Bone alkaline phosphatase (BAP), sclerostin, and DKK-1 were measured in serum by enzyme immunoassay. BMD was measured by dual-energy X-ray absorptiometry at the lumbar spine and in the whole skeleton. Biochemical indexes were also measured in 143 healthy controls (age range 4.5–27.4 years). HIV-infected patients had lower than normal BMD (spine P
AB - Reduced bone mineral density (BMD) and altered bone metabolism are common findings in HIV-infected patients. Increased bone formation has been described both in HIV-infected adults and children. Wnt ligands promote bone formation by stimulating osteoblast differentiation and their survival. Sclerostin and dickkopf factor 1 (DKK-1), Wnt antagonists, are important negative regulators of bone formation. We studied 86 HIV-infected patients whose ages ranged from 5.7 to 27.9 years. Patients were all on antiretroviral therapy, but seven who were naïve to treatment. Bone alkaline phosphatase (BAP), sclerostin, and DKK-1 were measured in serum by enzyme immunoassay. BMD was measured by dual-energy X-ray absorptiometry at the lumbar spine and in the whole skeleton. Biochemical indexes were also measured in 143 healthy controls (age range 4.5–27.4 years). HIV-infected patients had lower than normal BMD (spine P
KW - Bone mineral density
KW - DKK-1
KW - HIV infection
KW - Sclerostin
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U2 - 10.1007/s12020-015-0527-8
DO - 10.1007/s12020-015-0527-8
M3 - Article
C2 - 25596857
AN - SCOPUS:84937970092
VL - 49
SP - 783
EP - 790
JO - Endocrine
JF - Endocrine
SN - 1355-008X
IS - 3
ER -