Sclerostin and DKK-1: two important regulators of bone metabolism in HIV-infected youths

Stefano Mora, Maria Puzzovio, Vania Giacomet, Valentina Fabiano, Katia Maruca, Silvia Capelli, Pilar Nannini, Giovanni Lombardi, Gian Vincenzo Zuccotti

Research output: Contribution to journalArticlepeer-review

Abstract

Reduced bone mineral density (BMD) and altered bone metabolism are common findings in HIV-infected patients. Increased bone formation has been described both in HIV-infected adults and children. Wnt ligands promote bone formation by stimulating osteoblast differentiation and their survival. Sclerostin and dickkopf factor 1 (DKK-1), Wnt antagonists, are important negative regulators of bone formation. We studied 86 HIV-infected patients whose ages ranged from 5.7 to 27.9 years. Patients were all on antiretroviral therapy, but seven who were naïve to treatment. Bone alkaline phosphatase (BAP), sclerostin, and DKK-1 were measured in serum by enzyme immunoassay. BMD was measured by dual-energy X-ray absorptiometry at the lumbar spine and in the whole skeleton. Biochemical indexes were also measured in 143 healthy controls (age range 4.5–27.4 years). HIV-infected patients had lower than normal BMD (spine P 

Original languageEnglish
Pages (from-to)783-790
Number of pages8
JournalEndocrine
Volume49
Issue number3
DOIs
Publication statusPublished - Aug 27 2015

Keywords

  • Bone mineral density
  • DKK-1
  • HIV infection
  • Sclerostin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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