Scotin: A new p63 target gene expressed during epidermal differentiation

Loredana Zocchi, Jean Christophe Bourdon, Andrea Codispoti, Richard Knight, David P. Lane, Gerry Melino, Alessandro Terrinoni

Research output: Contribution to journalArticlepeer-review


p63, a member of the p53 family, is transcribed from two different promoters giving rise to two different proteins: TAp63 that contains the N-terminal transactivation domain and ΔN that lacks this domain. In this article we describe a new target gene Scotin induced by TAp63 during epithelial differentiation. This gene was previously isolated as a p53-inducible proapoptotic gene and the protein is located in the endoplasmic reticulum and in the nuclear membrane. Scotin expression is induced in response to endoplasmic reticulum (ER) stress in a p53 dependent or independent manner. We detected Scotin upregulation in primary keratinocyte cell lines committed to differentiate. In this paper we also show that Scotin is expressed in the supra basal layer of the epidermis in parallel with TAp63, but not ΔNp63 expression. We conclude that Scotin is a new p63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - Mar 7 2008


  • Epithelial differentiation
  • ER stress
  • GADD153
  • p63
  • Scotin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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