Scotin: A new p63 target gene expressed during epidermal differentiation

Loredana Zocchi, Jean Christophe Bourdon, Andrea Codispoti, Richard Knight, David P. Lane, Gerry Melino, Alessandro Terrinoni

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

p63, a member of the p53 family, is transcribed from two different promoters giving rise to two different proteins: TAp63 that contains the N-terminal transactivation domain and ΔN that lacks this domain. In this article we describe a new target gene Scotin induced by TAp63 during epithelial differentiation. This gene was previously isolated as a p53-inducible proapoptotic gene and the protein is located in the endoplasmic reticulum and in the nuclear membrane. Scotin expression is induced in response to endoplasmic reticulum (ER) stress in a p53 dependent or independent manner. We detected Scotin upregulation in primary keratinocyte cell lines committed to differentiate. In this paper we also show that Scotin is expressed in the supra basal layer of the epidermis in parallel with TAp63, but not ΔNp63 expression. We conclude that Scotin is a new p63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume367
Issue number2
DOIs
Publication statusPublished - Mar 7 2008

Fingerprint

Endoplasmic Reticulum Stress
Genes
Nuclear Envelope
Keratinocytes
Epidermis
Endoplasmic Reticulum
Transcriptional Activation
Proteins
Up-Regulation
Cells
Membranes
Cell Line

Keywords

  • Epithelial differentiation
  • ER stress
  • GADD153
  • p63
  • Scotin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Scotin : A new p63 target gene expressed during epidermal differentiation. / Zocchi, Loredana; Bourdon, Jean Christophe; Codispoti, Andrea; Knight, Richard; Lane, David P.; Melino, Gerry; Terrinoni, Alessandro.

In: Biochemical and Biophysical Research Communications, Vol. 367, No. 2, 07.03.2008, p. 271-276.

Research output: Contribution to journalArticle

Zocchi, Loredana ; Bourdon, Jean Christophe ; Codispoti, Andrea ; Knight, Richard ; Lane, David P. ; Melino, Gerry ; Terrinoni, Alessandro. / Scotin : A new p63 target gene expressed during epidermal differentiation. In: Biochemical and Biophysical Research Communications. 2008 ; Vol. 367, No. 2. pp. 271-276.
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