Scrambler Therapy® MC-5A for Complex Regional Pain Syndrome: Case Reports

Umberto Raucci, Caterina Tomasello, Marcello Marri, Marco Salzano, Augusto Gasparini, Elena Conicella

Research output: Contribution to journalArticlepeer-review


Background: Complex regional pain syndrome (CRPS) is a disorder that is often challenging to treat and can be associated with a prolonged course of severe pain. Therapy of CRPS remains controversial; the pain often can be very difficult to control, and treatment includes medications, physical therapy, regional anesthesia, and neuromodulation. Aim: We evaluated Scrambler Therapy® (ST) in terms of efficacy, safety, and durability of treatment effect in patients suffering from CRPS. Materials and Methods: We report the response to ST in four patients with CRPS referred to the Pain Center of Bambino Gesù Children's Hospital. The patients previously did not respond to conventional and nonconventional medical treatments. Results: The treatment with ST was found effective in all four of our patients; they obtained pain relief for long periods and an improvement in their quality of life. We observed a progressive improvement with complete disappearance of neuropathic pain. Patients also reported a muscle strength increase that allowed them to resume normal daily activities. Discussion and Conclusion: We conclude that ST may offer a therapeutic opportunity for patients with neuropathic pain resulting from CRPS, without side effects and with minimal discomfort during treatment. The observed pain relief indicates that ST could be an effective option for such patients.

Original languageEnglish
Pages (from-to)E103-E109
JournalPain Practice
Issue number7
Publication statusPublished - Sep 1 2016


  • chronic pain
  • complex regional pain syndrome
  • electrical pain stimulation
  • neuromodulation
  • neuropathic pain
  • nonconventional therapy
  • quality of life
  • Scrambler Therapy

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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