Screen-detected multiple primary lung cancers in the ITALUNG trial

Mario Mascalchi, Camilla Comin, Elena Bertelli, Lapo Sali, Cristina Maddau, Stefania Zuccherelli, Giulia Picozzi, Laura Carrozzi, Michela Grazzini, Gabriella Fontanini, Luca Voltolini, Alessandra Vella, Francesca Castiglione, Francesca Carozzi, Eugenio Paci, Maurizio Zompatori, Andrea Lopes Pegna, Fabio Falaschi, Roberto Bianchi, Cristina RonchiFerruccio Aquilini, Stella Cini, Mariella De Santis, Francesco Pistelli, Filomena Baliva, Antonio Chella, Laura Tavanti, Florio Innocenti, Ilaria Natali, Maurizio Bartolucci, Elena Crisci, Agostino De Francisci, Massimo Falchini, Silvia Gabbrielli, Giuliana Roselli, Andrea Masi, Luigi Battola, Anna Lisa De Liperi, Cheti Spinelli, Letizia Vannucchi, Alessia Petruzzelli, Davide Gadda, Anna Talina Neri, Franco Niccolai, Luca Vaggelli, Francesca Maria Carozzi, Alberto Janni, Alfredo Mussi, Marco Lucchi, Camilla Comin, For the ITALUNG Study Research Group

Research output: Contribution to journalArticle

Abstract

Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC in subjects recruited in the ITALUNG randomized clinical trial. Cases of cytologically/histologically proven MPLC detected at screening LDCT or follow-up CT were selected and pathologically re-evaluated according to the WHO 2015 classification. Overall 16 MPLC were diagnosed at screening LDCT (n=14, all present at baseline) or follow-up CT (n=2) in six subjects (4 in one subject, 3 in two and 2 in three subjects), representing 0.43% of the 1,406 screenees and 15.8% of the 38 subjects with at least one screen-detected primary lung cancer. MPLC included 9 adenocarcinomas in three subjects and a combination of 7 different tumour histotypes in three subjects. MPLC, mostly adenocarcinomas, are not uncommon in smokers and ex-smokers with at least one LDCT screen detected primary lung cancer.

Original languageEnglish
Pages (from-to)1058-1066
Number of pages9
JournalJournal of Thoracic Disease
Volume10
Issue number2
DOIs
Publication statusPublished - Feb 1 2018

Keywords

  • Adenocarcinoma
  • Low-dose CT screening
  • Lung cancer
  • Multiple primary lung cancer

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Screen-detected multiple primary lung cancers in the ITALUNG trial'. Together they form a unique fingerprint.

  • Cite this

    Mascalchi, M., Comin, C., Bertelli, E., Sali, L., Maddau, C., Zuccherelli, S., Picozzi, G., Carrozzi, L., Grazzini, M., Fontanini, G., Voltolini, L., Vella, A., Castiglione, F., Carozzi, F., Paci, E., Zompatori, M., Pegna, A. L., Falaschi, F., Bianchi, R., ... For the ITALUNG Study Research Group (2018). Screen-detected multiple primary lung cancers in the ITALUNG trial. Journal of Thoracic Disease, 10(2), 1058-1066. https://doi.org/10.21037/jtd.2018.01.95