Screen-detected multiple primary lung cancers in the ITALUNG trial

Mario Mascalchi, Camilla Comin, Elena Bertelli, Lapo Sali, Cristina Maddau, Stefania Zuccherelli, Giulia Picozzi, Laura Carrozzi, Michela Grazzini, Gabriella Fontanini, Luca Voltolini, Alessandra Vella, Francesca Castiglione, Francesca Carozzi, Eugenio Paci, Maurizio Zompatori, Andrea Lopes Pegna, Fabio Falaschi, Roberto Bianchi, Cristina RonchiFerruccio Aquilini, Stella Cini, Mariella De Santis, Francesco Pistelli, Filomena Baliva, Antonio Chella, Laura Tavanti, Florio Innocenti, Ilaria Natali, Maurizio Bartolucci, Elena Crisci, Agostino De Francisci, Massimo Falchini, Silvia Gabbrielli, Giuliana Roselli, Andrea Masi, Luigi Battola, Anna Lisa De Liperi, Cheti Spinelli, Letizia Vannucchi, Alessia Petruzzelli, Davide Gadda, Anna Talina Neri, Franco Niccolai, Luca Vaggelli, Francesca Maria Carozzi, Alberto Janni, Alfredo Mussi, Marco Lucchi, Camilla Comin, For the ITALUNG Study Research Group

Research output: Contribution to journalArticle

Abstract

Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC in subjects recruited in the ITALUNG randomized clinical trial. Cases of cytologically/histologically proven MPLC detected at screening LDCT or follow-up CT were selected and pathologically re-evaluated according to the WHO 2015 classification. Overall 16 MPLC were diagnosed at screening LDCT (n=14, all present at baseline) or follow-up CT (n=2) in six subjects (4 in one subject, 3 in two and 2 in three subjects), representing 0.43% of the 1,406 screenees and 15.8% of the 38 subjects with at least one screen-detected primary lung cancer. MPLC included 9 adenocarcinomas in three subjects and a combination of 7 different tumour histotypes in three subjects. MPLC, mostly adenocarcinomas, are not uncommon in smokers and ex-smokers with at least one LDCT screen detected primary lung cancer.

Original languageEnglish
Pages (from-to)1058-1066
Number of pages9
JournalJournal of Thoracic Disease
Volume10
Issue number2
DOIs
Publication statusPublished - Feb 1 2018

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Lung Neoplasms
Tomography
Adenocarcinoma
Randomized Controlled Trials
Neoplasms

Keywords

  • Adenocarcinoma
  • Low-dose CT screening
  • Lung cancer
  • Multiple primary lung cancer

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Mascalchi, M., Comin, C., Bertelli, E., Sali, L., Maddau, C., Zuccherelli, S., ... For the ITALUNG Study Research Group (2018). Screen-detected multiple primary lung cancers in the ITALUNG trial. Journal of Thoracic Disease, 10(2), 1058-1066. https://doi.org/10.21037/jtd.2018.01.95

Screen-detected multiple primary lung cancers in the ITALUNG trial. / Mascalchi, Mario; Comin, Camilla; Bertelli, Elena; Sali, Lapo; Maddau, Cristina; Zuccherelli, Stefania; Picozzi, Giulia; Carrozzi, Laura; Grazzini, Michela; Fontanini, Gabriella; Voltolini, Luca; Vella, Alessandra; Castiglione, Francesca; Carozzi, Francesca; Paci, Eugenio; Zompatori, Maurizio; Pegna, Andrea Lopes; Falaschi, Fabio; Bianchi, Roberto; Ronchi, Cristina; Aquilini, Ferruccio; Cini, Stella; De Santis, Mariella; Pistelli, Francesco; Baliva, Filomena; Chella, Antonio; Tavanti, Laura; Innocenti, Florio; Natali, Ilaria; Bartolucci, Maurizio; Crisci, Elena; De Francisci, Agostino; Falchini, Massimo; Gabbrielli, Silvia; Roselli, Giuliana; Masi, Andrea; Battola, Luigi; De Liperi, Anna Lisa; Spinelli, Cheti; Vannucchi, Letizia; Petruzzelli, Alessia; Gadda, Davide; Neri, Anna Talina; Niccolai, Franco; Vaggelli, Luca; Carozzi, Francesca Maria; Janni, Alberto; Mussi, Alfredo; Lucchi, Marco; Comin, Camilla; For the ITALUNG Study Research Group.

In: Journal of Thoracic Disease, Vol. 10, No. 2, 01.02.2018, p. 1058-1066.

Research output: Contribution to journalArticle

Mascalchi, M, Comin, C, Bertelli, E, Sali, L, Maddau, C, Zuccherelli, S, Picozzi, G, Carrozzi, L, Grazzini, M, Fontanini, G, Voltolini, L, Vella, A, Castiglione, F, Carozzi, F, Paci, E, Zompatori, M, Pegna, AL, Falaschi, F, Bianchi, R, Ronchi, C, Aquilini, F, Cini, S, De Santis, M, Pistelli, F, Baliva, F, Chella, A, Tavanti, L, Innocenti, F, Natali, I, Bartolucci, M, Crisci, E, De Francisci, A, Falchini, M, Gabbrielli, S, Roselli, G, Masi, A, Battola, L, De Liperi, AL, Spinelli, C, Vannucchi, L, Petruzzelli, A, Gadda, D, Neri, AT, Niccolai, F, Vaggelli, L, Carozzi, FM, Janni, A, Mussi, A, Lucchi, M, Comin, C & For the ITALUNG Study Research Group 2018, 'Screen-detected multiple primary lung cancers in the ITALUNG trial', Journal of Thoracic Disease, vol. 10, no. 2, pp. 1058-1066. https://doi.org/10.21037/jtd.2018.01.95
Mascalchi M, Comin C, Bertelli E, Sali L, Maddau C, Zuccherelli S et al. Screen-detected multiple primary lung cancers in the ITALUNG trial. Journal of Thoracic Disease. 2018 Feb 1;10(2):1058-1066. https://doi.org/10.21037/jtd.2018.01.95
Mascalchi, Mario ; Comin, Camilla ; Bertelli, Elena ; Sali, Lapo ; Maddau, Cristina ; Zuccherelli, Stefania ; Picozzi, Giulia ; Carrozzi, Laura ; Grazzini, Michela ; Fontanini, Gabriella ; Voltolini, Luca ; Vella, Alessandra ; Castiglione, Francesca ; Carozzi, Francesca ; Paci, Eugenio ; Zompatori, Maurizio ; Pegna, Andrea Lopes ; Falaschi, Fabio ; Bianchi, Roberto ; Ronchi, Cristina ; Aquilini, Ferruccio ; Cini, Stella ; De Santis, Mariella ; Pistelli, Francesco ; Baliva, Filomena ; Chella, Antonio ; Tavanti, Laura ; Innocenti, Florio ; Natali, Ilaria ; Bartolucci, Maurizio ; Crisci, Elena ; De Francisci, Agostino ; Falchini, Massimo ; Gabbrielli, Silvia ; Roselli, Giuliana ; Masi, Andrea ; Battola, Luigi ; De Liperi, Anna Lisa ; Spinelli, Cheti ; Vannucchi, Letizia ; Petruzzelli, Alessia ; Gadda, Davide ; Neri, Anna Talina ; Niccolai, Franco ; Vaggelli, Luca ; Carozzi, Francesca Maria ; Janni, Alberto ; Mussi, Alfredo ; Lucchi, Marco ; Comin, Camilla ; For the ITALUNG Study Research Group. / Screen-detected multiple primary lung cancers in the ITALUNG trial. In: Journal of Thoracic Disease. 2018 ; Vol. 10, No. 2. pp. 1058-1066.
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abstract = "Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC in subjects recruited in the ITALUNG randomized clinical trial. Cases of cytologically/histologically proven MPLC detected at screening LDCT or follow-up CT were selected and pathologically re-evaluated according to the WHO 2015 classification. Overall 16 MPLC were diagnosed at screening LDCT (n=14, all present at baseline) or follow-up CT (n=2) in six subjects (4 in one subject, 3 in two and 2 in three subjects), representing 0.43{\%} of the 1,406 screenees and 15.8{\%} of the 38 subjects with at least one screen-detected primary lung cancer. MPLC included 9 adenocarcinomas in three subjects and a combination of 7 different tumour histotypes in three subjects. MPLC, mostly adenocarcinomas, are not uncommon in smokers and ex-smokers with at least one LDCT screen detected primary lung cancer.",
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AU - Mascalchi, Mario

AU - Comin, Camilla

AU - Bertelli, Elena

AU - Sali, Lapo

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AU - Zuccherelli, Stefania

AU - Picozzi, Giulia

AU - Carrozzi, Laura

AU - Grazzini, Michela

AU - Fontanini, Gabriella

AU - Voltolini, Luca

AU - Vella, Alessandra

AU - Castiglione, Francesca

AU - Carozzi, Francesca

AU - Paci, Eugenio

AU - Zompatori, Maurizio

AU - Pegna, Andrea Lopes

AU - Falaschi, Fabio

AU - Bianchi, Roberto

AU - Ronchi, Cristina

AU - Aquilini, Ferruccio

AU - Cini, Stella

AU - De Santis, Mariella

AU - Pistelli, Francesco

AU - Baliva, Filomena

AU - Chella, Antonio

AU - Tavanti, Laura

AU - Innocenti, Florio

AU - Natali, Ilaria

AU - Bartolucci, Maurizio

AU - Crisci, Elena

AU - De Francisci, Agostino

AU - Falchini, Massimo

AU - Gabbrielli, Silvia

AU - Roselli, Giuliana

AU - Masi, Andrea

AU - Battola, Luigi

AU - De Liperi, Anna Lisa

AU - Spinelli, Cheti

AU - Vannucchi, Letizia

AU - Petruzzelli, Alessia

AU - Gadda, Davide

AU - Neri, Anna Talina

AU - Niccolai, Franco

AU - Vaggelli, Luca

AU - Carozzi, Francesca Maria

AU - Janni, Alberto

AU - Mussi, Alfredo

AU - Lucchi, Marco

AU - Comin, Camilla

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