Screening and management of HIV-2-infected individuals in Northern Italy

Silvia Costarelli, Carlo Torti, Anna Rodella, Fausto Baldanti, Stefania Paolucci, Giuseppe Lapadula, Nino Manca, Eugenia Quiros-Roldan, Ilaria Izzo, Giampiero Carosi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

There is a lack of updated estimates of HIV-2 infection in Italy. Moreover, lack of standardized HIV-2 viral load (VL) and drug resistance tests challenges clinical practice. Among 2941 HIV-positive patients followed in our center (Brescia, Northern Italy), 220 (7.5%) were African at the beginning of the study period. We assessed a population of 151 HIV-Ab positive patients (141 of African origin), presenting for routine blood testing from January 2006 to May 2007. Those found infected with HIV-2 started an appropriate disease management with HIV-2 VL and genotypic drug resistance testing. Sixteen of 151 (10.6%) patients were positive for HIV-2. Of those 16 patients, 14 came from Africa. Among 7 experienced patients, 1 was responding to nelfinavir and 4 to lopinavir/ritonavir-containing regimens. Two patients were failing treatment: 1 patient was switched to a saquinavir/ritonavir-containing regimen and responded. The remaining patient switched to lamivudine+atazanavir+saquinavir+ritonavir did not respond, having had previous experience to multiple ineffective drugs, resulting in a very complex HIV-2 drug-resistance pattern. Accurate screening programs and integration of virological tools must be implemented urgently, given the high prevalence of HIV-2, particularly in immigrant patients.

Original languageEnglish
Pages (from-to)489-494
Number of pages6
JournalAIDS Patient Care and STDs
Volume22
Issue number6
DOIs
Publication statusPublished - Jun 1 2008

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HIV-2
Italy
Ritonavir
Saquinavir
Viral Load
Drug Resistance
Viral Drug Resistance
HIV
Nelfinavir
Lopinavir
Lamivudine
Disease Management
HIV Infections

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Leadership and Management
  • Nursing(all)

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Screening and management of HIV-2-infected individuals in Northern Italy. / Costarelli, Silvia; Torti, Carlo; Rodella, Anna; Baldanti, Fausto; Paolucci, Stefania; Lapadula, Giuseppe; Manca, Nino; Quiros-Roldan, Eugenia; Izzo, Ilaria; Carosi, Giampiero.

In: AIDS Patient Care and STDs, Vol. 22, No. 6, 01.06.2008, p. 489-494.

Research output: Contribution to journalArticle

Costarelli, S, Torti, C, Rodella, A, Baldanti, F, Paolucci, S, Lapadula, G, Manca, N, Quiros-Roldan, E, Izzo, I & Carosi, G 2008, 'Screening and management of HIV-2-infected individuals in Northern Italy', AIDS Patient Care and STDs, vol. 22, no. 6, pp. 489-494. https://doi.org/10.1089/apc.2007.0149
Costarelli, Silvia ; Torti, Carlo ; Rodella, Anna ; Baldanti, Fausto ; Paolucci, Stefania ; Lapadula, Giuseppe ; Manca, Nino ; Quiros-Roldan, Eugenia ; Izzo, Ilaria ; Carosi, Giampiero. / Screening and management of HIV-2-infected individuals in Northern Italy. In: AIDS Patient Care and STDs. 2008 ; Vol. 22, No. 6. pp. 489-494.
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