Screening and mutational improvement of a D-ribose secreting Candida pelliculosa strain

Peter De Wulf, Wim Soetaert, Dieter Schwengers, Erick Jerome Vandamme

Research output: Contribution to journalArticlepeer-review


The application of D-ribose in chemistry and pharmacy lately has received much attention. In order to develop an efficient D-ribose production process, a screening strategy was established to isolate naturally occurring D-ribose secreting microorganisms. Of the more than two thousand strains isolated, only four excreted D-ribose in a range from 0.04 to 0.36 g/l, starting from 30 g/l of D-glucose. One strain, identified as Candida pelliculosa, quantitatively co-produced D-arabitol (up to 7 g/l). This strain was subsequently submitted to UV-mutagenesis and a selective nystatin-based enrichment, leading to the isolation of a D-arabitol non-secreting mutant (C. pelliculosa PDW 43 ARA-), which synthesized 5 g/l of D-ribose from 30 g/l of D-glucose.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Fermentation and Bioengineering
Issue number1
Publication statusPublished - 1996


  • Candida pelliculosa
  • D-arabitol
  • D-ribose
  • mutation
  • screening
  • transketolase

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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