Screening for Aphasia in NeuroDegeneration for the Diagnosis of Patients with Primary Progressive Aphasia: Clinical Validity and Psychometric Properties

Petronilla Battista, Eleonora Catricalà, Marco Piccininni, Massimiliano Copetti, Valentina Esposito, Cristina Polito, Antonio Miozzo, Elena Gobbi, Sofia Cuoco, Veronica Boschi, Marina Picillo, Sandro Sorbi, Paolo Barone, Sandro Iannaccone, Peter Garrard, Giancarlo Logroscino, Stefano F. Cappa

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We evaluated the psychometric proprieties of the Screening for Aphasia in NeuroDegeneration (SAND) battery in Italian primary progressive aphasia (PPA) and movement disorder (MD) patients. Methods: The sample included 30 consecutive PPA and 45 MD patients who completed the SAND battery together with a clinical interview and a neurological/neuropsychological examination and 130 healthy controls (HC). Results: The SAND battery showed good internal consistency and good convergent and divergent validity. receiver operating characteristic analysis revealed an area under the curve of 0.978 for PPA versus HC and of 0.786 for PPA versus MD. A cutoff ≥3 gave a sensitivity of 0.933% and a specificity of 0.946% for discriminating PPA versus HC, whereas a cutoff ≥5 gave a sensitivity of 0.767% and a specificity of 0.667% for discriminating PPA versus MD. Conclusion: These results indicate that the SAND battery is an adequate, reliable, and valid diagnostic tool for PPA.

Original languageEnglish
Pages (from-to)243-252
Number of pages10
JournalDementia and Geriatric Cognitive Disorders
DOIs
Publication statusPublished - Oct 2018

Keywords

  • Dementia
  • Diagnostic accuracy
  • Language impairment
  • Screening instrument
  • Speech-language assessment

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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