Screening for aphasia in neurodegeneration for the diagnosis of patients with primary progressive aphasia: Clinical validity and psychometric properties

P Battista, E Catricalà, M Piccininni, M Copetti, V Esposito, C Polito, A Miozzo, E Gobbi, S Cuoco, V Boschi, M Picillo, S Sorbi, P Barone, S Iannaccone, P Garrard, G Logroscino, SF Cappa

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Abstract

Background: We evaluated the psychometric proprieties of the Screening for Aphasia in NeuroDegeneration (SAND) battery in Italian primary progressive aphasia (PPA) and movement disorder (MD) patients. Methods: The sample included 30 consecutive PPA and 45 MD patients who completed the SAND battery together with a clinical interview and a neurological/neuropsychological examination and 130 healthy controls (HC). Results: The SAND battery showed good internal consistency and good convergent and divergent validity. receiver operating characteristic analysis revealed an area under the curve of 0.978 for PPA versus HC and of 0.786 for PPA versus MD. A cutoff ≥3 gave a sensitivity of 0.933% and a specificity of 0.946% for discriminating PPA versus HC, whereas a cutoff ≥5 gave a sensitivity of 0.767% and a specificity of 0.667% for discriminating PPA versus MD. Conclusion: These results indicate that the SAND battery is an adequate, reliable, and valid diagnostic tool for PPA. © 2018 S. Karger AG, Basel. All rights reserved.
Original languageEnglish
Pages (from-to)243-252
Number of pages10
JournalDementia and Geriatric Cognitive Disorders
Volume46
Issue number3-4
DOIs
Publication statusPublished - 2018

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Battista, P., Catricalà, E., Piccininni, M., Copetti, M., Esposito, V., Polito, C., Miozzo, A., Gobbi, E., Cuoco, S., Boschi, V., Picillo, M., Sorbi, S., Barone, P., Iannaccone, S., Garrard, P., Logroscino, G., & Cappa, SF. (2018). Screening for aphasia in neurodegeneration for the diagnosis of patients with primary progressive aphasia: Clinical validity and psychometric properties. Dementia and Geriatric Cognitive Disorders, 46(3-4), 243-252. https://doi.org/10.1159/000492632