Lo screening degli aneurismi cerebrali nella popolazione ADPKD: un esame irrinunciabile o una procedura potenzialmente dannosa?

Translated title of the contribution: [Screening for cerebral aneurysms in the ADPKD population: mandatory or potentially harmful?].

Riccardo Magistroni, Lucia Palmieri, Francesco Scolari

Research output: Contribution to journalArticle

Abstract

Cerebral aneurysm in autosomal dominant polycystic kidney disease (ADPKD) is an uncommon event (documented in 6-13% of cases) but frequently characterized by severe neurological sequelae and potentially fatal in case of rupture. The arterial vascular wall of the anterior cerebral circulation is most frequently involved. Experimental data showed the expression of polycystins (the proteins modified by the mutation in this disease) in the affected arterial vascular wall and some mutations apparently give rise to greater susceptibility to the complication. The risk factors that cause the predisposition to this condition and the natural history are poorly understood. This lack of information complicates the clinical management of these patients because many pivotal questions still need an answer: Are cerebral aneurysms to be screened for in the ADPKD population? If so, at which intervals? In which cases where an aneurysm has been detected is correction needed? Which type of correction technique is to be preferred, interventional neuroradiology or neurosurgery? The three authors compare their partially discordant positions on this highly controversial topic.

Original languageItalian
Pages (from-to)582-587
Number of pages6
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume28
Issue number6
Publication statusPublished - Nov 2011

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Autosomal Dominant Polycystic Kidney
Intracranial Aneurysm
Blood Vessels
Cerebrovascular Circulation
TRPP Cation Channels
Mutation
Neurosurgery
Natural History
Population
Aneurysm
Rupture
Proteins

ASJC Scopus subject areas

  • Nephrology

Cite this

Lo screening degli aneurismi cerebrali nella popolazione ADPKD : un esame irrinunciabile o una procedura potenzialmente dannosa? / Magistroni, Riccardo; Palmieri, Lucia; Scolari, Francesco.

In: Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, Vol. 28, No. 6, 11.2011, p. 582-587.

Research output: Contribution to journalArticle

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