Screening for melas point mutation at position 3243 of mitochondria!. dna in migraine

C. Casali, G. Di Gennaro, O. Ciccarelli, D. Fortini, F. Naso, A. Amabile, F. Pierelli

Research output: Contribution to journalArticle

Abstract

The association between migraine and impaired mitochondrial function has been suggested by several clinical, biochemical and neuroradiologic findings. Indeed, migrainous headache with vomiting and cerebral infarctions, most often in the posterior cerebral region, are clinical features found both in the MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes) and, as complication, in idiopatic migraine. Moreover, biochemical analysis revealed depression of platelet and muscle mitochondrial enzyme activities, while 31 posphorous- Magnetic Resonance Spectroscopy studies confirmed an impaired energy metabolism in brain and muscle of migrainous patients. Finally, maternal inheritance, frequently found in migraine, suggests mt-DNA mutations. The aim of our study was to determine whether at least a subgroup of migrainous patients are affected by a monosymptomatic form of MELAS syndrome. We therefore, looked for the most common MELAS point mutation (at 3243nt in the tRNAUu(UUR) gene of mtDNA) in 21 migrainous patients with affected mothers. We failed to detect MELAS mutation and therefore, these data do not support the mitochondrial hypothesis of migraine This result cannot exlude, however, that a subgroup of migraine may still be associated with other point mutations of mtDNA or of nuclear genome related to mitochondrial function.

Original languageEnglish
Pages (from-to)93
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

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MELAS Syndrome
Migraine Disorders
Point Mutation
Mitochondria
Mitochondrial DNA
Muscles
Mutation
Cerebral Infarction
Energy Metabolism
Vomiting
Headache
Magnetic Resonance Spectroscopy
Blood Platelets
Mothers
Genome
DNA
Brain
Enzymes
Genes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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Screening for melas point mutation at position 3243 of mitochondria!. dna in migraine. / Casali, C.; Di Gennaro, G.; Ciccarelli, O.; Fortini, D.; Naso, F.; Amabile, A.; Pierelli, F.

In: Italian Journal of Neurological Sciences, Vol. 18, No. 4, 1997, p. 93.

Research output: Contribution to journalArticle

Casali, C. ; Di Gennaro, G. ; Ciccarelli, O. ; Fortini, D. ; Naso, F. ; Amabile, A. ; Pierelli, F. / Screening for melas point mutation at position 3243 of mitochondria!. dna in migraine. In: Italian Journal of Neurological Sciences. 1997 ; Vol. 18, No. 4. pp. 93.
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AU - Amabile, A.

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