Screening of a microvascular endothelial cDNA library identifies rabaptin 5 as a novel autoantigen in Alzheimer's disease

Federica Delunardo, Paola Margutti, Simona Pontecorvo, Tania Colasanti, Fabrizio Conti, Rachele Riganò, Elisabetta Profumo, Alessandra Siracusano, Antonella Capozzi, Massimiliano Prencipe, Maurizio Sorice, Ada Francia, Elena Ortona

Research output: Contribution to journalArticle

Abstract

The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of patients with AD and in 35% of patients with systemic lupus erythematosus, but in no healthy controls. Our results demonstrated a massive redistribution of this protein in the cytoplasm of endothelial and neuronal cells in apoptosis. In conclusion, we identified RABPT5 as a novel autoantigen in AD.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalJournal of Neuroimmunology
Volume192
Issue number1-2
DOIs
Publication statusPublished - Dec 2007

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Keywords

  • Alzheimer's disease
  • Autoantibodies
  • Endothelial cells
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Delunardo, F., Margutti, P., Pontecorvo, S., Colasanti, T., Conti, F., Riganò, R., Profumo, E., Siracusano, A., Capozzi, A., Prencipe, M., Sorice, M., Francia, A., & Ortona, E. (2007). Screening of a microvascular endothelial cDNA library identifies rabaptin 5 as a novel autoantigen in Alzheimer's disease. Journal of Neuroimmunology, 192(1-2), 105-112. https://doi.org/10.1016/j.jneuroim.2007.09.027