TY - JOUR
T1 - Screening of a microvascular endothelial cDNA library identifies rabaptin 5 as a novel autoantigen in Alzheimer's disease
AU - Delunardo, Federica
AU - Margutti, Paola
AU - Pontecorvo, Simona
AU - Colasanti, Tania
AU - Conti, Fabrizio
AU - Riganò, Rachele
AU - Profumo, Elisabetta
AU - Siracusano, Alessandra
AU - Capozzi, Antonella
AU - Prencipe, Massimiliano
AU - Sorice, Maurizio
AU - Francia, Ada
AU - Ortona, Elena
PY - 2007/12
Y1 - 2007/12
N2 - The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of patients with AD and in 35% of patients with systemic lupus erythematosus, but in no healthy controls. Our results demonstrated a massive redistribution of this protein in the cytoplasm of endothelial and neuronal cells in apoptosis. In conclusion, we identified RABPT5 as a novel autoantigen in AD.
AB - The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of patients with AD and in 35% of patients with systemic lupus erythematosus, but in no healthy controls. Our results demonstrated a massive redistribution of this protein in the cytoplasm of endothelial and neuronal cells in apoptosis. In conclusion, we identified RABPT5 as a novel autoantigen in AD.
KW - Alzheimer's disease
KW - Autoantibodies
KW - Endothelial cells
KW - Systemic lupus erythematosus
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U2 - 10.1016/j.jneuroim.2007.09.027
DO - 10.1016/j.jneuroim.2007.09.027
M3 - Article
C2 - 17961730
AN - SCOPUS:36749023917
VL - 192
SP - 105
EP - 112
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -