Abstract
The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of patients with AD and in 35% of patients with systemic lupus erythematosus, but in no healthy controls. Our results demonstrated a massive redistribution of this protein in the cytoplasm of endothelial and neuronal cells in apoptosis. In conclusion, we identified RABPT5 as a novel autoantigen in AD.
| Original language | English |
|---|---|
| Pages (from-to) | 105-112 |
| Number of pages | 8 |
| Journal | Journal of Neuroimmunology |
| Volume | 192 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Dec 2007 |
Fingerprint
Keywords
- Alzheimer's disease
- Autoantibodies
- Endothelial cells
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology
Cite this
Screening of a microvascular endothelial cDNA library identifies rabaptin 5 as a novel autoantigen in Alzheimer's disease. / Delunardo, Federica; Margutti, Paola; Pontecorvo, Simona; Colasanti, Tania; Conti, Fabrizio; Riganò, Rachele; Profumo, Elisabetta; Siracusano, Alessandra; Capozzi, Antonella; Prencipe, Massimiliano; Sorice, Maurizio; Francia, Ada; Ortona, Elena.
In: Journal of Neuroimmunology, Vol. 192, No. 1-2, 12.2007, p. 105-112.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Screening of a microvascular endothelial cDNA library identifies rabaptin 5 as a novel autoantigen in Alzheimer's disease
AU - Delunardo, Federica
AU - Margutti, Paola
AU - Pontecorvo, Simona
AU - Colasanti, Tania
AU - Conti, Fabrizio
AU - Riganò, Rachele
AU - Profumo, Elisabetta
AU - Siracusano, Alessandra
AU - Capozzi, Antonella
AU - Prencipe, Massimiliano
AU - Sorice, Maurizio
AU - Francia, Ada
AU - Ortona, Elena
PY - 2007/12
Y1 - 2007/12
N2 - The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of patients with AD and in 35% of patients with systemic lupus erythematosus, but in no healthy controls. Our results demonstrated a massive redistribution of this protein in the cytoplasm of endothelial and neuronal cells in apoptosis. In conclusion, we identified RABPT5 as a novel autoantigen in AD.
AB - The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of patients with AD and in 35% of patients with systemic lupus erythematosus, but in no healthy controls. Our results demonstrated a massive redistribution of this protein in the cytoplasm of endothelial and neuronal cells in apoptosis. In conclusion, we identified RABPT5 as a novel autoantigen in AD.
KW - Alzheimer's disease
KW - Autoantibodies
KW - Endothelial cells
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=36749023917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36749023917&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2007.09.027
DO - 10.1016/j.jneuroim.2007.09.027
M3 - Article
VL - 192
SP - 105
EP - 112
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -