Screening of cognitive impairment in chronic obstructive pulmonary disease

Raffaele Antonelli-Incalzi, Andrea Corsonello, Luigi Trojano, Claudio Pedone, Domenico Acanfora, Aldo Spada, Orsola Izzo, Franco Rengo

Research output: Contribution to journalArticlepeer-review


Cognitive dysfunction is common and clinically important in severe chronic obstructive pulmonary disease (COPD). We investigated the diagnostic accuracy of the Mini Mental State Examination (MMSE) and Instrumental Activities of Daily Living (IADL) scale in screening severe cognitive dysfunction in 149 patients with COPD, mean age 69.3 ± 8.5 years, forced expiratory volume in 1 s = 36.6 ± 17.8% of the predicted. Patients underwent the MMSE and an in-depth neuropsychological assessment based upon the Mental Deterioration Battery (MDB). The 5-item IADL scale was assessed. The sample was randomly divided into a training (n = 73) and a testing (n = 76) population. The diagnostic accuracy of MMSE, IADL scale or both versus cognitive dysfunction corresponding to abnormal performance in 3 or more MDB tests was assessed in the training population and the model obtained was tested in the testing population. The combination of MMSE

Original languageEnglish
Pages (from-to)264-270
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Issue number4
Publication statusPublished - Mar 2007


  • Chronic obstructive pulmonary disease
  • Cognitive impairment
  • Instrumental activities of daily living
  • Mini mental state examination

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology


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