Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

Estefanía Abascal, Marta Herranz, Fermín Acosta, Juan Agapito, Andrea M. Cabibbe, Johana Monteserin, María Jesús Ruiz Serrano, Paloma Gijón, Francisco Fernández-González, Nuria Lozano, Álvaro Chiner-Oms, Tatiana Cáceres, Pilar Gómez Pintado, Enrique Acín, Eddy Valencia, Patricia Muñoz, Iñaki Comas, Daniela M. Cirillo, Viviana Ritacco, Eduardo GotuzzoDarío García de Viedma

Research output: Contribution to journalArticlepeer-review

Abstract

It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR–clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002–5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.

Original languageEnglish
Article number2704
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - Dec 1 2020

ASJC Scopus subject areas

  • General

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