Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections: Scientific Reports

E. Abascal, M. Herranz, F. Acosta, J. Agapito, A.M. Cabibbe, J. Monteserin, M.J. Ruiz Serrano, P. Gijón, F. Fernández-González, N. Lozano, Á. Chiner-Oms, T. Cáceres, P.G. Pintado, E. Acín, E. Valencia, P. Muñoz, I. Comas, D.M. Cirillo, V. Ritacco, E. GotuzzoD. García de Viedma

Research output: Contribution to journalArticlepeer-review

Abstract

It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR–clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002–5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection. © 2020, The Author(s).
Original languageEnglish
Article number2704
JournalSci. Rep.
Volume10
Issue number1
DOIs
Publication statusPublished - 2020

Keywords

  • tuberculostatic agent
  • bacterium identification
  • genetics
  • human
  • isolation and purification
  • lung tuberculosis
  • mass screening
  • microbiology
  • mixed infection
  • molecular epidemiology
  • multidrug resistance
  • multidrug resistant tuberculosis
  • Mycobacterium tuberculosis
  • pathogenicity
  • patient transport
  • Peru
  • prevalence
  • prison
  • prisoner
  • Spain
  • Antitubercular Agents
  • Bacterial Typing Techniques
  • Coinfection
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Mass Screening
  • Molecular Epidemiology
  • Patient Transfer
  • Prevalence
  • Prisoners
  • Prisons
  • Tuberculosis, Multidrug-Resistant
  • Tuberculosis, Pulmonary

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