Screening dei tumori endocrini pancreatico-duodenali nei pazienti con MEN-1: confronto tra TC multistrato ed eco-endoscopia

Translated title of the contribution: Screening of pancreaticoduodenal endocrine tumours in patients with MEN 1: Multidetector-row computed tomography vs. endoscopic ultrasound

L. Camera, S. Paoletta, C. Mollica, F. Milone, V. Napolitano, L. De Luca, A. Faggiano, A. Colao, M. Salvatore

Research output: Contribution to journalArticle

Abstract

Purpose: The authors compared multidetector-row computed tomography (MDCT) and endoscopic ultrasound (EUS) in the identification of pancreaticoduodenal endocrine tumours (PETs) in patients with multiple endocrine neoplasia type 1 (MEN 1). Materials and methods: Fourteen consecutive patients (eight men and six women, aged 26-54 years) with MEN 1 underwent MDCT performed with a 4- (n=5) or 64- (n=9) detector-row system and EUS done with a radial transducer (7.5-20 MHz) within 7-28 days of each other. Prior to MDCT examination, patients were given 750 cc of water and asked to lie down in the right lateral decubitus for 15 min. Multiphase MDCT images were acquired both before and after the injection of nonionic iodinated contrast material (2 cc/kg) at an injection rate of 4 ml/s, with technical parameters and scan delay varying in relation to the system used. Images were all reconstructed at 3-mm intervals for the three phases (arterial, pancreatic and portal) and evaluated on a dedicated workstation. Results: MDCT detected a total of 25 PETs (3-18 mm) in nine patients. Of these lesions, nine were situated within the duodenal wall and 16 in either the pancreatic head (n=3), body (n=7), or tail (n=6). Three additional lesions were detected retrospectively after EUS imaging. Most (18/22, 81%) were hypervascular nodules, and four appeared as either hypoattenuating or cystic lesions. EUS detected a total of 32 PETs (2-18 mm) in 11 patients. Most lesions (29/32, 90%) appeared hypoechoic and were situated in the duodenal wall (n=15) or in either the pancreatic head (n=10), body (n=6) or tail (n=1). Conclusions: Our preliminary data indicate that MDCT is complementary to EUS in the identification of PETs in MEN-1 patients.

Original languageItalian
Pages (from-to)595-606
Number of pages12
JournalRadiologia Medica
Volume116
Issue number4
DOIs
Publication statusPublished - Jun 2011

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Multiple Endocrine Neoplasia Type 1
Multidetector Computed Tomography
Neoplasms
Injections
Transducers
Contrast Media
Ultrasonography
Water

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Screening dei tumori endocrini pancreatico-duodenali nei pazienti con MEN-1 : confronto tra TC multistrato ed eco-endoscopia. / Camera, L.; Paoletta, S.; Mollica, C.; Milone, F.; Napolitano, V.; De Luca, L.; Faggiano, A.; Colao, A.; Salvatore, M.

In: Radiologia Medica, Vol. 116, No. 4, 06.2011, p. 595-606.

Research output: Contribution to journalArticle

Camera, L, Paoletta, S, Mollica, C, Milone, F, Napolitano, V, De Luca, L, Faggiano, A, Colao, A & Salvatore, M 2011, 'Screening dei tumori endocrini pancreatico-duodenali nei pazienti con MEN-1: confronto tra TC multistrato ed eco-endoscopia', Radiologia Medica, vol. 116, no. 4, pp. 595-606. https://doi.org/10.1007/s11547-011-0636-2
Camera, L. ; Paoletta, S. ; Mollica, C. ; Milone, F. ; Napolitano, V. ; De Luca, L. ; Faggiano, A. ; Colao, A. ; Salvatore, M. / Screening dei tumori endocrini pancreatico-duodenali nei pazienti con MEN-1 : confronto tra TC multistrato ed eco-endoscopia. In: Radiologia Medica. 2011 ; Vol. 116, No. 4. pp. 595-606.
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abstract = "Purpose: The authors compared multidetector-row computed tomography (MDCT) and endoscopic ultrasound (EUS) in the identification of pancreaticoduodenal endocrine tumours (PETs) in patients with multiple endocrine neoplasia type 1 (MEN 1). Materials and methods: Fourteen consecutive patients (eight men and six women, aged 26-54 years) with MEN 1 underwent MDCT performed with a 4- (n=5) or 64- (n=9) detector-row system and EUS done with a radial transducer (7.5-20 MHz) within 7-28 days of each other. Prior to MDCT examination, patients were given 750 cc of water and asked to lie down in the right lateral decubitus for 15 min. Multiphase MDCT images were acquired both before and after the injection of nonionic iodinated contrast material (2 cc/kg) at an injection rate of 4 ml/s, with technical parameters and scan delay varying in relation to the system used. Images were all reconstructed at 3-mm intervals for the three phases (arterial, pancreatic and portal) and evaluated on a dedicated workstation. Results: MDCT detected a total of 25 PETs (3-18 mm) in nine patients. Of these lesions, nine were situated within the duodenal wall and 16 in either the pancreatic head (n=3), body (n=7), or tail (n=6). Three additional lesions were detected retrospectively after EUS imaging. Most (18/22, 81{\%}) were hypervascular nodules, and four appeared as either hypoattenuating or cystic lesions. EUS detected a total of 32 PETs (2-18 mm) in 11 patients. Most lesions (29/32, 90{\%}) appeared hypoechoic and were situated in the duodenal wall (n=15) or in either the pancreatic head (n=10), body (n=6) or tail (n=1). Conclusions: Our preliminary data indicate that MDCT is complementary to EUS in the identification of PETs in MEN-1 patients.",
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AU - Camera, L.

AU - Paoletta, S.

AU - Mollica, C.

AU - Milone, F.

AU - Napolitano, V.

AU - De Luca, L.

AU - Faggiano, A.

AU - Colao, A.

AU - Salvatore, M.

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N2 - Purpose: The authors compared multidetector-row computed tomography (MDCT) and endoscopic ultrasound (EUS) in the identification of pancreaticoduodenal endocrine tumours (PETs) in patients with multiple endocrine neoplasia type 1 (MEN 1). Materials and methods: Fourteen consecutive patients (eight men and six women, aged 26-54 years) with MEN 1 underwent MDCT performed with a 4- (n=5) or 64- (n=9) detector-row system and EUS done with a radial transducer (7.5-20 MHz) within 7-28 days of each other. Prior to MDCT examination, patients were given 750 cc of water and asked to lie down in the right lateral decubitus for 15 min. Multiphase MDCT images were acquired both before and after the injection of nonionic iodinated contrast material (2 cc/kg) at an injection rate of 4 ml/s, with technical parameters and scan delay varying in relation to the system used. Images were all reconstructed at 3-mm intervals for the three phases (arterial, pancreatic and portal) and evaluated on a dedicated workstation. Results: MDCT detected a total of 25 PETs (3-18 mm) in nine patients. Of these lesions, nine were situated within the duodenal wall and 16 in either the pancreatic head (n=3), body (n=7), or tail (n=6). Three additional lesions were detected retrospectively after EUS imaging. Most (18/22, 81%) were hypervascular nodules, and four appeared as either hypoattenuating or cystic lesions. EUS detected a total of 32 PETs (2-18 mm) in 11 patients. Most lesions (29/32, 90%) appeared hypoechoic and were situated in the duodenal wall (n=15) or in either the pancreatic head (n=10), body (n=6) or tail (n=1). Conclusions: Our preliminary data indicate that MDCT is complementary to EUS in the identification of PETs in MEN-1 patients.

AB - Purpose: The authors compared multidetector-row computed tomography (MDCT) and endoscopic ultrasound (EUS) in the identification of pancreaticoduodenal endocrine tumours (PETs) in patients with multiple endocrine neoplasia type 1 (MEN 1). Materials and methods: Fourteen consecutive patients (eight men and six women, aged 26-54 years) with MEN 1 underwent MDCT performed with a 4- (n=5) or 64- (n=9) detector-row system and EUS done with a radial transducer (7.5-20 MHz) within 7-28 days of each other. Prior to MDCT examination, patients were given 750 cc of water and asked to lie down in the right lateral decubitus for 15 min. Multiphase MDCT images were acquired both before and after the injection of nonionic iodinated contrast material (2 cc/kg) at an injection rate of 4 ml/s, with technical parameters and scan delay varying in relation to the system used. Images were all reconstructed at 3-mm intervals for the three phases (arterial, pancreatic and portal) and evaluated on a dedicated workstation. Results: MDCT detected a total of 25 PETs (3-18 mm) in nine patients. Of these lesions, nine were situated within the duodenal wall and 16 in either the pancreatic head (n=3), body (n=7), or tail (n=6). Three additional lesions were detected retrospectively after EUS imaging. Most (18/22, 81%) were hypervascular nodules, and four appeared as either hypoattenuating or cystic lesions. EUS detected a total of 32 PETs (2-18 mm) in 11 patients. Most lesions (29/32, 90%) appeared hypoechoic and were situated in the duodenal wall (n=15) or in either the pancreatic head (n=10), body (n=6) or tail (n=1). Conclusions: Our preliminary data indicate that MDCT is complementary to EUS in the identification of PETs in MEN-1 patients.

KW - Endoscopic ultrasonography (EUS)

KW - Multidetector CT (MDCT)

KW - Multiple endocrine neoplasia (MEN) 1

KW - Pancreaticoduodenal endocrine tumours

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