Screening of pharmaceuticals and illicit drugs in wastewater and surface waters of Spain and Italy by high resolution mass spectrometry using UHPLC-QTOF MS and LC-LTQ-Orbitrap MS

Richard Bade, Nikolaos I. Rousis, Lubertus Bijlsma, Emma Gracia-Lor, Sara Castiglioni, Juan V. Sancho, Felix Hernandez

Research output: Contribution to journalArticle

Abstract

The existence of pharmaceuticals and illicit drugs (PIDs) in environmental waters has led many analytical chemists to develop screening methods for monitoring purposes. Water samples can contain a huge number of possible contaminants, commonly at low concentrations, which makes their detection and identification problematic. Liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) has proven itself effective in the screening of environmental contaminants. The present work investigates the use of the most popular HRMS instruments, quadrupole time-of-flight and linear trap quadrupole-Orbitrap, from two different laboratories. A suspect screening for PIDs was carried out on wastewater (influent and effluent) and surface water samples from Castellón, Eastern Spain, and Cremona, Northern Italy, incorporating a database of 107 PIDs (including 220 fragment ions). A comparison between the findings of both instruments and of the samples was made which highlights the advantages and drawbacks of the strategies applied in each case. In total, 28 compounds were detected and/or identified by either/both instruments with irbesartan, valsartan, benzoylecgonine and caffeine being the most commonly found compounds across all samples. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)8979-8988
Number of pages10
JournalAnalytical and Bioanalytical Chemistry
Volume407
Issue number30
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Street Drugs
Waste Water
Surface waters
Spain
Italy
Mass spectrometry
Mass Spectrometry
Screening
Wastewater
irbesartan
Valsartan
Water
Pharmaceutical Databases
Pharmaceutical Preparations
Impurities
Liquid chromatography
Caffeine
Liquid Chromatography
Effluents
Ions

Keywords

  • High resolution mass spectrometry
  • Illicit drugs
  • Liquid chromatography
  • Pharmaceuticals
  • Screening

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Screening of pharmaceuticals and illicit drugs in wastewater and surface waters of Spain and Italy by high resolution mass spectrometry using UHPLC-QTOF MS and LC-LTQ-Orbitrap MS. / Bade, Richard; Rousis, Nikolaos I.; Bijlsma, Lubertus; Gracia-Lor, Emma; Castiglioni, Sara; Sancho, Juan V.; Hernandez, Felix.

In: Analytical and Bioanalytical Chemistry, Vol. 407, No. 30, 01.12.2015, p. 8979-8988.

Research output: Contribution to journalArticle

Bade, Richard ; Rousis, Nikolaos I. ; Bijlsma, Lubertus ; Gracia-Lor, Emma ; Castiglioni, Sara ; Sancho, Juan V. ; Hernandez, Felix. / Screening of pharmaceuticals and illicit drugs in wastewater and surface waters of Spain and Italy by high resolution mass spectrometry using UHPLC-QTOF MS and LC-LTQ-Orbitrap MS. In: Analytical and Bioanalytical Chemistry. 2015 ; Vol. 407, No. 30. pp. 8979-8988.
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