Scurvy: still a threat in the well-fed first world?

Giulia Ceglie, Giulia Macchiarulo, Maria Rosaria Marchili, Alessandra Marchesi, Lelia Rotondi Aufiero, Chiara Di Camillo, Alberto Villani

Research output: Contribution to journalReview article

Abstract

We report three cases of scurvy in previously healthy children referred to us for leg pain and refusal to walk. All children had no significant medical history, symptoms had started months before and subtly advanced. Two of them presented with gingival hyperplasia and petechiae, another one reported night sweats and gingival bleeding in the past few weeks. Two had vitamin D deficiency, and all had microcytic anaemia (in one case requiring transfusional support). A nutritional screening revealed low or undetectable levels of ascorbic acid. This, along with the clinical and radiological findings, led to a diagnosis of scurvy. Vitamin C supplementation was started with rapid improvement of the children's clinical condition. Scurvy is a rare disease in the 'first world', but there are anecdotal reports of scurvy in children without any of the known risk factors for this condition. In our cases, a selective diet was the only risk factor.

Original languageEnglish
JournalArchives of Disease in Childhood
DOIs
Publication statusE-pub ahead of print - Aug 7 2018

Fingerprint

Scurvy
Ascorbic Acid
Gingival Hyperplasia
Vitamin D Deficiency
Purpura
Sweat
Rare Diseases
Anemia
Leg
Hemorrhage
Diet
Pain

Cite this

Scurvy : still a threat in the well-fed first world? / Ceglie, Giulia; Macchiarulo, Giulia; Marchili, Maria Rosaria; Marchesi, Alessandra; Rotondi Aufiero, Lelia; Di Camillo, Chiara; Villani, Alberto.

In: Archives of Disease in Childhood, 07.08.2018.

Research output: Contribution to journalReview article

Ceglie, Giulia ; Macchiarulo, Giulia ; Marchili, Maria Rosaria ; Marchesi, Alessandra ; Rotondi Aufiero, Lelia ; Di Camillo, Chiara ; Villani, Alberto. / Scurvy : still a threat in the well-fed first world?. In: Archives of Disease in Childhood. 2018.
@article{e29406393c924559b0f17b508f3dab5b,
title = "Scurvy: still a threat in the well-fed first world?",
abstract = "We report three cases of scurvy in previously healthy children referred to us for leg pain and refusal to walk. All children had no significant medical history, symptoms had started months before and subtly advanced. Two of them presented with gingival hyperplasia and petechiae, another one reported night sweats and gingival bleeding in the past few weeks. Two had vitamin D deficiency, and all had microcytic anaemia (in one case requiring transfusional support). A nutritional screening revealed low or undetectable levels of ascorbic acid. This, along with the clinical and radiological findings, led to a diagnosis of scurvy. Vitamin C supplementation was started with rapid improvement of the children's clinical condition. Scurvy is a rare disease in the 'first world', but there are anecdotal reports of scurvy in children without any of the known risk factors for this condition. In our cases, a selective diet was the only risk factor.",
author = "Giulia Ceglie and Giulia Macchiarulo and Marchili, {Maria Rosaria} and Alessandra Marchesi and {Rotondi Aufiero}, Lelia and {Di Camillo}, Chiara and Alberto Villani",
note = "{\circledC} Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2018",
month = "8",
day = "7",
doi = "10.1136/archdischild-2018-315496",
language = "English",
journal = "Archives of Disease in Childhood",
issn = "0003-9888",
publisher = "BMJ Publishing Group",

}

TY - JOUR

T1 - Scurvy

T2 - still a threat in the well-fed first world?

AU - Ceglie, Giulia

AU - Macchiarulo, Giulia

AU - Marchili, Maria Rosaria

AU - Marchesi, Alessandra

AU - Rotondi Aufiero, Lelia

AU - Di Camillo, Chiara

AU - Villani, Alberto

N1 - © Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2018/8/7

Y1 - 2018/8/7

N2 - We report three cases of scurvy in previously healthy children referred to us for leg pain and refusal to walk. All children had no significant medical history, symptoms had started months before and subtly advanced. Two of them presented with gingival hyperplasia and petechiae, another one reported night sweats and gingival bleeding in the past few weeks. Two had vitamin D deficiency, and all had microcytic anaemia (in one case requiring transfusional support). A nutritional screening revealed low or undetectable levels of ascorbic acid. This, along with the clinical and radiological findings, led to a diagnosis of scurvy. Vitamin C supplementation was started with rapid improvement of the children's clinical condition. Scurvy is a rare disease in the 'first world', but there are anecdotal reports of scurvy in children without any of the known risk factors for this condition. In our cases, a selective diet was the only risk factor.

AB - We report three cases of scurvy in previously healthy children referred to us for leg pain and refusal to walk. All children had no significant medical history, symptoms had started months before and subtly advanced. Two of them presented with gingival hyperplasia and petechiae, another one reported night sweats and gingival bleeding in the past few weeks. Two had vitamin D deficiency, and all had microcytic anaemia (in one case requiring transfusional support). A nutritional screening revealed low or undetectable levels of ascorbic acid. This, along with the clinical and radiological findings, led to a diagnosis of scurvy. Vitamin C supplementation was started with rapid improvement of the children's clinical condition. Scurvy is a rare disease in the 'first world', but there are anecdotal reports of scurvy in children without any of the known risk factors for this condition. In our cases, a selective diet was the only risk factor.

U2 - 10.1136/archdischild-2018-315496

DO - 10.1136/archdischild-2018-315496

M3 - Review article

C2 - 30087152

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 0003-9888

ER -